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Table 2 Association of the iron-related SNPs with non-invasive measurements of atherosclerosis

From: Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?

    Presence of plaque IMT ABI at rest ABI after exercise
SNP – Tested allele CHR:BP (Build 37) Freq H* OR 95 % CI H* Beta 95 % CI H* Beta 95 % CI H* Beta 95 % CI
Multi-SNP score               
Q1    Ref Ref Ref Ref Ref Ref Ref Ref Ref Ref Ref Ref
Q2    >1 1.06 0.66; 1.71 + −0.024 −0.051; 0.002 - 0.003 −0.022; 0.028 - −0.024 −0.051; 0.002
Q3    >1 0.82 0.51; 1.34 + −0.007 −0.034; 0.020 - 0.005 −0.021; 0.030 - −0.007 −0.034; 0.020
Q4    >1 1.13 0.70; 1.82 + 0.009 −0.018; 0.036 - 0.003 −0.022; 0.028 - 0.009 −0.018; 0.036
rs744653 – T 2:190,378,750 0.86 <1 1.10 0.78; 1.55 - −0.006 −0.025; 0.014 + −0.013 −0.031; 0.005 + −0.019 −0.052; 0.014
rs8177240 – T† 3:133,477,701 0.66 ? 1.13 0.87; 1.46 ? −0.010 −0.025; 0.004 ? 0.014 0.000; 0.027 ? 0.030 0.005; 0.055
rs9990333 – T 3:195,827,205 0.47 >1 1.32 1.03; 1.68 + 0.012 −0.002; 0.025 - 0.006 −0.006; 0.019 - 0.016 −0.007; 0.040
rs1800562 – A 6: 26,093,141 0.06 >1 1.03 0.62; 1.69 + −0.017 −0.045; 0.011 - −0.006 −0.032; 0.020 - −0.005 −0.054; 0.043
rs1799945 – C 6: 26,091,179 0.84 <1 1.19 0.86; 1.64 - 0.011 −0.007; 0.029 + 0.003 −0.014; 0.019 + −0.006 −0.037; 0.024
rs7385804 – A 7: 100,235,970 0.64 >1 0.92 0.72; 1.18 + −0.006 −0.020; 0.008 - 0.000 −0.013; 0.013 - 0.018 −0.006; 0.042
rs4921915 – A‡ 8: 18,272,466 0.78 ? 1.42 1.04; 1.92 ? −0.006 −0.023; 0.010 ? 0.002 −0.014; 0.017 ? 0.005 −0.023; 0.034
rs651007 – T 9: 136,153,875 0.20 <1 0.84 0.62; 1.15 - −0.021 −0.038; 0.004 + 0.003 −0.013; 0.019 + 0.034 0.004; 0.063
rs6486121 – T‡ 11: 13,355,770 0.64 ? 0.94 0.73; 1.20 ? 0.012 −0.002; 0.026 ? −0.004 −0.017; 0.009 ? −0.007 −0.031; 0.018
rs174577 – A‡ 11: 61,604,814 0.32 ? 1.10 0.85; 1.42 ? 0.001 −0.013; 0.015 ? 0.004 −0.009; 0.017 ? 0.015 −0.009; 0.040
rs411988 – A 17: 56,709,034 0.58 <1 0.92 0.73;1.17 - −0.001 −0.015; 0.012 + 0.004 −0.008; 0.017 + −0.010 −0.033; 0.013
rs855791 – A 22: 37,462,936 0.46 <1 1.20 0.94; 1.54 - −0.010 −0.023; 0.004 + 0.005 −0.008; 0.018 + 0.010 −0.013; 0.034
  1. Associations were tested using logistic (presence of plaque) and linear regression (IMT and ABI at rest and after exercise). Resulting odds ratios (OR) of logistic models for the multi-SNP score express the change in odds for presence of plaque relative to Q1. Resulting betas of linear models for the multi-SNP score express the change in IMT or ABI using Q1 as a reference, thus Q2 vs Q1, Q3 vs Q1 and Q4 vs Q1. Resulting ORs of logistic regression models for the single SNP analyses express the effect of each extra tested allele on odds for presence of plaque. Resulting betas of linear models for the single SNP analyses express the effect of each extra tested allele on IMT or ABI. Tested alleles are the same as in the original publication [23]. Nominally significant associations are indicated in bold
  2. ABI indicates ankle-brachial index, CHR:BP chromosome:base-pair position, CI confidence interval, Freq frequency of tested allele, H hypothesized effect, IMT intima media thickness, OR odds ratio, Ref reference, Q quartile, SNP single nucleotide polymorphism
  3. *Hypothesized effect on the NIMA according to the ‘iron hypothesis’ (see Fig. 1). Presence of plaque, a higher IMT and a lower ABI indicate presence of atherosclerosis
  4. †This SNP decreases iron and transferrin and increases TS, so the hypothesized effect on atherosclerosis is unknown
  5. ‡These SNPs only show association with transferrin, so the hypothesized effect on atherosclerosis is unknown