| |
Most strongly associated SNP in discovery
|
Most strongly associated SNP in validation
| |
---|
BTCa
|
Interval (Mbp)b
|
SNP
|
Position (bP)
|
-log10 (P)
|
Effect ± SE
|
MAFc
|
\( \frac{\sigma_a^2}{\sigma_p^2} \) (%)d
|
SNP
|
Position (bp)
|
-log10 (P)
|
Effect ± SE
|
MAF
|
\( \frac{\sigma_a^2}{\sigma_p^2} \) (%)
|
Genes
|
---|
5
|
12.551 - 13.463
|
rs133249083
|
13027942
|
4.139
|
2.462 ± 0.620
|
0.329
|
0.095
|
rs135584613
|
13270757
|
3.229
|
−3.077 ± 0.893
|
0.325
|
0.140
|
NA
|
5
|
88.607 - 89.159
|
rs135833682
|
88822777
|
4.076
|
−2.191 ± 0.556
|
0.417
|
0.083
|
rs133539520
|
88861488
|
2.679
|
−2.784 ± 0.934
|
0.313
|
0.112
|
ABCC9
|
9
|
55.233 - 55.657
|
rs134339497
|
55233033
|
4.325
|
−2.364 ± 0.580
|
0.402
|
0.096
|
rs136630637
|
55637401
|
2.399
|
−2.559 ± 0.887
|
0.337
|
0.098
|
NA
|
9
|
57.397 - 57.735
|
rs137407787
|
57396816
|
4.130
|
−2.346 ± 0.591
|
0.358
|
0.091
|
rs42550144
|
57723628
|
2.408
|
−2.685 ± 0.929
|
0.290
|
0.100
|
EPHA7
|
9
|
60.121 - 60.477
|
rs43600502
|
60477358
|
5.195
|
−2.642 ± 0.584
|
0.352
|
0.114
|
rs133175600
|
60130790
|
2.127
|
2.813 ± 1.05
|
0.212
|
0.087
|
LOC101902479
|
11
|
20.620 – 21.274
|
rs133774241
|
20994163
|
4.318
|
−2.706 ± 0.665
|
0.241
|
0.096
|
rs137059194
|
20898669
|
2.410
|
−2.467 ± 0.8529
|
0.458
|
0.101
|
LOC783737
|
11
|
39.466 - 39.772
|
rs109315341
|
39466071
|
4.126
|
−2.971 ± 0.749
|
0.177
|
0.092
|
rs133126268
|
39747182
|
2.408
|
−3.706 ± 1.284
|
0.115
|
0.094
|
NA
|
11
|
40.896 - 41.299
|
rs133462686
|
41298588
|
4.491
|
−3.036 ± 0.729
|
0.182
|
0.098
|
rs109834745
|
40895791
|
2.414
|
3.554 ± 1.228
|
0.139
|
0.101
|
LOC101903002
|
18
|
4.541 - 4.810
|
rs109920290
|
4541123
|
4.326
|
2.4 ± 0.589
|
0.391
|
0.098
|
rs110689012
|
4810082
|
2.044
|
3.37 ± 1.29
|
0.119
|
0.080
|
NA
|
18
|
37.446 - 37.925
|
rs41875426
|
37446338
|
4.061
|
2.679 ± 0.682
|
0.213
|
0.086
|
rs137407722
|
37925382
|
3.142
|
4.111 ± 1.213
|
0.147
|
0.142
|
NA
|
18
|
53.789 - 54.605
|
rs41891477
|
54232476
|
4.180
|
−2.302 ± 0.576
|
0.399
|
0.091
|
rs109907036
|
54028686
|
3.680
|
4.065 ± 1.094
|
0.186
|
0.168
|
PRKD2 / PPP5C
|
18
|
57.109 - 58.052
|
rs110801791
|
57516245
|
4.675
|
−3.508 ± 0.824
|
0.136
|
0.103
|
rs41895542
|
57269152
|
2.496
|
3.6 ± 1.219
|
0.133
|
0.100
|
NA
|
18
|
61.922 - 62.150
|
rs133761590
|
62115202
|
4.661
|
2.525 ± 0.594
|
0.369
|
0.106
|
rs137170802
|
62143810
|
2.736
|
−3.018 ± 0.966
|
0.255
|
0.116
|
CACNG6 / VSTM1
|
22
|
4.979 - 5.598
|
rs41996522
|
5028345
|
6.076
|
−2.784 ± 0.564
|
0.442
|
0.137
|
rs41995585
|
5133660
|
2.168
|
−3.028 ± 1.117
|
0.168
|
0.086
|
NA
|
27
|
41.873 - 42.109
|
rs134294374
|
42079983
|
5.581
|
−2.76 ± 0.586
|
0.367
|
0.127
|
rs41586304
|
41872925
|
2.295
|
3.105 ± 1.107
|
0.176
|
0.094
|
NR1D2
|
27
|
43.595 - 44.261
|
rs110746407
|
43914360
|
6.075
|
−2.781 ± 0.564
|
0.441
|
0.136
| |
rs43064076
|
43595406
|
2.873
|
−3.831 ± 1.192
|
0.146
|
0.123
|
NA
|
X
|
139.211 - 139.509
|
rs136627433
|
139508886
|
4.679
|
−2.606 ± 0.6098
|
0.394
|
0.116
| |
rs110719178
|
139490243
|
2.320
|
−3.327 ± 1.175
|
0.163
|
0.101
|
NA
|
-
aBTC: Bos Taurus chromosome
-
bIntervals containing individually validated SNPs are in bold
-
c
MAF minor allele frequency
-
d
σ
2
a
= additive variance; σ
2
p
= phenotypic variance