Table 4 Boundaries of the validated regions with significant additive effects on milk yield and the most significant SNPs within the identified regions with their associated genes in discovery and validation populations
Most strongly associated SNP in discovery | Most strongly associated SNP in validation | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BTCa | Interval (Mbp)b | SNP | Position (bp) | -log10 (P) | Effect ± SE | MAFc | \( \frac{\sigma_a^2}{\sigma_p^2} \) (%)d | SNP | Position (bp) | Effect ± SE | -log10 (P) | MAF | \( \frac{\sigma_a^2}{\sigma_p^2} \) (%) | Genese |
5 | 94.453 - 95.026 | rs136374794 | 94518850 | 11.633 | 120.3 ± 17.11 | 0.300 | 0.490 | rs136816685 | 95001236 | −80.76 ± 16.46 | 6.013 | 0.471 | 0.459 | PTPRO |
5 | 96.927 - 97.854 | rs110729080 | 97435197 | 8.791 | 149.8 ± 24.79 | 0.117 | 0.373 | rs134869818 | 97031962 | 97.04 ± 16.57 | 8.291 | 0.452 | 0.660 | GPRC5Af |
14 | 1.428 - 5.289 | rs109421300 | 1801116 | 134.354 | −389.4 ± 15.34 | 0.369 | 5.694 | rs109421300 | 1801116 | −234.1 ± 17.53 | 38.947 | 0.468 | 3.858 | DGAT1 f |
20 | 29.568 - 30.367 | rs134175348 | 30001269 | 7.230 | −104.6 ± 19.27 | 0.206 | 0.289 | rs42276093 | 29568029 | −133.9 ± 19.25 | 11.382 | 0.270 | 0.999 | NA |