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Table 4 Boundaries of the validated regions with significant additive effects on milk yield and the most significant SNPs within the identified regions with their associated genes in discovery and validation populations

From: Validation of markers with non-additive effects on milk yield and fertility in Holstein and Jersey cows

   Most strongly associated SNP in discovery Most strongly associated SNP in validation  
BTCa Interval (Mbp)b SNP Position (bp) -log10 (P) Effect ± SE MAFc \( \frac{\sigma_a^2}{\sigma_p^2} \) (%)d SNP Position (bp) Effect ± SE -log10 (P) MAF \( \frac{\sigma_a^2}{\sigma_p^2} \) (%) Genese
5 94.453 - 95.026 rs136374794 94518850 11.633 120.3 ± 17.11 0.300 0.490 rs136816685 95001236 −80.76 ± 16.46 6.013 0.471 0.459 PTPRO
5 96.927 - 97.854 rs110729080 97435197 8.791 149.8 ± 24.79 0.117 0.373 rs134869818 97031962 97.04 ± 16.57 8.291 0.452 0.660 GPRC5Af
14 1.428 - 5.289 rs109421300 1801116 134.354 −389.4 ± 15.34 0.369 5.694 rs109421300 1801116 −234.1 ± 17.53 38.947 0.468 3.858 DGAT1 f
20 29.568 - 30.367 rs134175348 30001269 7.230 −104.6 ± 19.27 0.206 0.289 rs42276093 29568029 −133.9 ± 19.25 11.382 0.270 0.999 NA
  1. aBTC: Bos Taurus chromosome
  2. bIntervals containing individually validated SNPs are in bold
  3. c MAF minor allele frequency
  4. d σ 2 a = additive variance; σ 2 p = phenotypic variance
  5. eGenes with both top SNPs in discovery and validation inside them are in bold
  6. fGenes with individually validated SNPs within them