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Table 1 Codons under selective pressure as inferred by algorithms of FEL, REL and SLAC analysis

From: MECP2, a gene associated with Rett syndrome in humans, shows conserved coding regions, independent Alu insertions, and a novel transcript across primate evolution

FEL analysis REL analysis SLAC analysis
Codon under selection Normalized dN-dS (p-value) Codon under selection Normalized E [dN-dS] (posterior probability) Codon under selection dN-dS (p-value)
24 -54.388 (0.015)     
26 -64.692 (0.001) 26 -5.640 (0.999)   
28 -23.921 (0.015)     
   38* -0.001 (0.834)   
45 -25.058 (0.037)     
48 -28.501 (0.029)     
50 -116.021 (0.001) 50 -8.259 (0.999) 50 -3.401 (0.037)
54 -74.389 (0.001) 54 -8.845 (1) 54 -5.668 (0.004)
62 -171.052 (0.000) 62 -11.116 (1 62 -6.802 (0.001)
64 -53.205 (0.006) 64 -4.313 (0.999)   
68 -121.797 (0.000) 68 -10.816 (1) 68 -5.668 (0.005)
69 -25.298 (0.046)     
70 -22.768 (0.024)     
72 -35.866 (0.020)     
75 -61.881 (0.002) 75 -6.324 (0.999) 75 -3.401 (0.037)
81 -43.081 (0.021)     
100 -19.480 (0.045)     
107 -95.287 (0.002) 107 -8.043 (0.999) 107 -3.944 (0.025)
109 -60.174 (0.011) 109 -4.356 (0.999)   
140 -35.109 (0.022)     
201 -40.376 (0.017)     
216 -23.921 (0.042)     
221 -44.476 (0.002) 221 -3.753 (0.999) 221 -4.380 (0.014)
229 -120.451 (0.000) 229 -10.822 (1) 229 -5.668 (0.004)
251 -46.877 (0.005) 251 -4.290 (0.999) 251 -4.535 (0.012)
252 -37.440 (0.025)     
257 -203.416 (0.000) 257 -11.114 (1) 257 -9.469 (0.000)
259 -39.143 (0.012) 259 -3.068 (0.999) 259 -3.401 (0.037)
272 -202.211 (0.000) 272 -11.134 (1) 272 -6.802 (0.001)
278 -36.279 (0.013) 278 -2.750 (0.999) 278 -3.401 (0.037)
280 -43.065 (0.009) 280 -3.467 (0.999) 280 -3.401 (0.037)
281 -52.084 (0.006) 281 -4.529 (0.999) 281 -3.401 (0.037)
311 -92.609 (0.000) 311 -9.538 (1) 311 -4.535 (0.012)
314 -90.671 (0.000) 314 -9.087 (0.9999) 314 -5.034 (0.008)
327 -41.076 (0.009) 327 -3.273 (0.999) 327 -4.466 (0.016)
328 -38.107 (0.005) 328 -2.958 (0.999) 328 -3.401 (0.037)
332 -29.179 (0.029)     
342 -86.299 (0.000) 342 -9.663 (1) 342 -5.668 (0.004)
   359* 0.085 (0.875)   
361 -40.741 (0.009)     
380 -96.464 (0.002) 380 -8.703 (0.999) 380 -6.060 (0.012)
   381 * -0.078 (0.797)   
382 -113.953 (0.001) 382 -9.995 (1) 382 -7.575 (0.004)
     390 -4.545 (0.037)
     392 -4.545 (0.037)
394 -32.544 (0.041)     
420 -37.880 (0.029)     
425 -24.576 (0.032)     
428 -54.374 (0.010) 428 -4.557 (0.999) 428 -4.190 (0.019)
441 -21.464 (0.028)     
443 -23.477 (0.038)     
  1. Marked sites with asterisk are under positive selection. Unmarked sites are under negative selection. PARRIS and MEME did not show evidence of positive selection
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