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Table 1 Codons under selective pressure as inferred by algorithms of FEL, REL and SLAC analysis

From: MECP2, a gene associated with Rett syndrome in humans, shows conserved coding regions, independent Alu insertions, and a novel transcript across primate evolution

FEL analysis

REL analysis

SLAC analysis

Codon under selection

Normalized dN-dS (p-value)

Codon under selection

Normalized E [dN-dS] (posterior probability)

Codon under selection

dN-dS (p-value)

24

-54.388 (0.015)

    

26

-64.692 (0.001)

26

-5.640 (0.999)

  

28

-23.921 (0.015)

    
  

38*

-0.001 (0.834)

  

45

-25.058 (0.037)

    

48

-28.501 (0.029)

    

50

-116.021 (0.001)

50

-8.259 (0.999)

50

-3.401 (0.037)

54

-74.389 (0.001)

54

-8.845 (1)

54

-5.668 (0.004)

62

-171.052 (0.000)

62

-11.116 (1

62

-6.802 (0.001)

64

-53.205 (0.006)

64

-4.313 (0.999)

  

68

-121.797 (0.000)

68

-10.816 (1)

68

-5.668 (0.005)

69

-25.298 (0.046)

    

70

-22.768 (0.024)

    

72

-35.866 (0.020)

    

75

-61.881 (0.002)

75

-6.324 (0.999)

75

-3.401 (0.037)

81

-43.081 (0.021)

    

100

-19.480 (0.045)

    

107

-95.287 (0.002)

107

-8.043 (0.999)

107

-3.944 (0.025)

109

-60.174 (0.011)

109

-4.356 (0.999)

  

140

-35.109 (0.022)

    

201

-40.376 (0.017)

    

216

-23.921 (0.042)

    

221

-44.476 (0.002)

221

-3.753 (0.999)

221

-4.380 (0.014)

229

-120.451 (0.000)

229

-10.822 (1)

229

-5.668 (0.004)

251

-46.877 (0.005)

251

-4.290 (0.999)

251

-4.535 (0.012)

252

-37.440 (0.025)

    

257

-203.416 (0.000)

257

-11.114 (1)

257

-9.469 (0.000)

259

-39.143 (0.012)

259

-3.068 (0.999)

259

-3.401 (0.037)

272

-202.211 (0.000)

272

-11.134 (1)

272

-6.802 (0.001)

278

-36.279 (0.013)

278

-2.750 (0.999)

278

-3.401 (0.037)

280

-43.065 (0.009)

280

-3.467 (0.999)

280

-3.401 (0.037)

281

-52.084 (0.006)

281

-4.529 (0.999)

281

-3.401 (0.037)

311

-92.609 (0.000)

311

-9.538 (1)

311

-4.535 (0.012)

314

-90.671 (0.000)

314

-9.087 (0.9999)

314

-5.034 (0.008)

327

-41.076 (0.009)

327

-3.273 (0.999)

327

-4.466 (0.016)

328

-38.107 (0.005)

328

-2.958 (0.999)

328

-3.401 (0.037)

332

-29.179 (0.029)

    

342

-86.299 (0.000)

342

-9.663 (1)

342

-5.668 (0.004)

  

359*

0.085 (0.875)

  

361

-40.741 (0.009)

    

380

-96.464 (0.002)

380

-8.703 (0.999)

380

-6.060 (0.012)

  

381 *

-0.078 (0.797)

  

382

-113.953 (0.001)

382

-9.995 (1)

382

-7.575 (0.004)

    

390

-4.545 (0.037)

    

392

-4.545 (0.037)

394

-32.544 (0.041)

    

420

-37.880 (0.029)

    

425

-24.576 (0.032)

    

428

-54.374 (0.010)

428

-4.557 (0.999)

428

-4.190 (0.019)

441

-21.464 (0.028)

    

443

-23.477 (0.038)

    
  1. Marked sites with asterisk are under positive selection. Unmarked sites are under negative selection. PARRIS and MEME did not show evidence of positive selection