Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region

Table 1 Changes in relative expression of 19 genes within tumor suppressor region located at 62.3 – 63.0 Mb (RNO10q24) distal to Tp53

Transcript	Position (Mb)	Group EC vs NME			Group EC with vs EC without loss at RNO10q24
Transcript	Position (Mb)	P-value	<0.05	Fold change	P-value	<0.05
Est1a	62.23	0.002	x	−2.3	0.03	x
Hic1	62.47	0.0004	x	−4.9	0.2
Ovca2	62.48	0.760
Dph1	62.49	0.973
Rtn4rl1	62.50	0.008	x	−4.5	0.02	x
Rpa1	62.61	0.003	x	−1.9	1.1
Smyd4	62.66	0.918
Serpinf1	62.71	0.293
Serpinf2	62.75	0.324
Wdr81	62.76	0.00.5	x	−1.7	0.01	x
Tlcd2	62.79	0.218
Prf8	62.81	0.054
Rilp	62.83	0.108
Scarf1	62.84	0.811
Slc43a2	62.85	0.247
Pitpn	62.91	0.0003	x	−2.2	0.0004	x
Inpp5k	62.95	0.0003	x	−6.8	0.2
Myo1c	62.99	0.000003	x	−4.8	0.1
Crk	63.02	0.00001	x	−3.2	0.4

Nine genes displayed significant decreased expression (nominal p-value < 0.05) in EC compared to the NME samples. Tumors were then divided into two groups of with and without deletion/AI at RNO10q24 and the gene expression data for the nine down regulated genes were reanalyzed. Down regulation of five genes (marked in bold) was not correlated with physical deletion at RNO10q24
Fold changes and P-values of the different transcripts. The negative values of fold change represent a decreased expression. FC shown only for genes displaying P-values <0.05 between NME vs EC
Equal variances assumed. t-test for equality of means

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