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Fig. 4 | BMC Genetics

Fig. 4

From: Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region

Fig. 4

Expression patterns of Hic1, Inpp5k and Myo1c after treatments with 5-Aza-dC and/or TSA in four tumors (NUT12 & NUT50 with and NUT51 & NUT98 without deletion in the candidate region) and one control (rat embryonic fibroblast, REF) samples. The results shown are representative of two independent experiments. a Hic1 mRNA expression, b Inpp5k mRNA expression, c Myo1c mRNA expression, d protein expression of Hic1 and Myo1c, and e quantification of Western blot analysis for Hic1 and Myo1c expressions. As shown, expression of Hic1 was not specifically restored in these assays (only after AZA treatment in one sample, NUT51), whereas expressions of Myo1c (at both mRNA and protein levels) and Inpp5k (at mRNA level) were restored after either or both of these treatments. Interestingly, restoration of Myo1c gene expression was observed in both tumors with (NUT12) and without (NUT98) AI/deletion in the region

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BMC Genomic Data

ISSN: 2730-6844

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