P53 codon 72 polymorphism, human papillomavirus infection, and their interaction to oral carcinoma susceptibility

BMC Genomic Data

Table 3 Association, test heterogeneity and publication bias for p53 Arg72Pro polymorphism and the risk of oral cancer

Comparison	Number of studies	Sample size (case/control)	Test of association				Test of heterogeneity			Publication bias
Comparison	Number of studies	Sample size (case/control)	OR	95 %CI	P value	Model	Q	P value	I²	P value (Begg’s)	P value (Egger’s)
Arg72 allele vs. Pro72 allele
Total	12	2,093/2,880	1.054	0.905-1.228	0.500	R	33.16	0.000	66.8 %	0.300	0.202
Caucasian	4	827/1,299	0.933	0.722-1.206	0.597	R	9.92	0.019	69.7 %	0.221	0.175
Asian	8	1,266/1,581	1.128	0.934-1.362	0.210	R	19.40	0.007	63.9 %	0.902	0.717
Arg/Arg vs. Pro/Pro
Total	12	2,093/2,880	1.109	0.807-1.524	0.523	R	29.39	0.002	62.6 %	0.360	0.415
Caucasian	4	827/1,299	0.870	0.621-1.218	0.416	F	6.04	0.110	50.3 %	0.462	0.312
Asian	8	1,266/1,581	1.277	0.860-1.898	0.226	R	19.36	0.007	63.8 %	0.536	0.914
Arg/Arg + Arg/Pro vs. Pro/Pro
Total	12	2,093/2,880	0.936	0.723-1.211	0.613	R	23.90	0.013	54.0 %	0.161	0.423
Caucasian	4	827/1,299	1.142	0.823-1.583	0.427	F	3.81	0.283	21.2 %	0.806	0.451
Asian	8	1,266/1,581	0.846	0.613-1.169	0.312	R	17.10	0.017	59.1 %	0.711	0.990
Arg/Arg vs. Arg/Pro + Pro/Pro
Total	13	2,413/3,201	1.069	0.907-1.259	0.426	R	23.56	0.023	49.1 %	0.511	0.302
Caucasian	5	1,147/1,620	0.975	0.777-1.224	0.828	R	8.54	0.074	53.2 %	0.060	0.054
Asian	8	1,266/1,581	1.161	0.917-1.471	0.215	R	13.19	0.068	46.9 %	0.902	0.883
HPV infection	5	396/213	0.677	0.478-0.959	0.027	F	0.93	0.920	0.0 %	0.462	0.400

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