From: Epigenetic modifications of caveolae associated proteins in health and disease
Cancer types | Promoter hypermethylation | Histone modification | CAV1 expression | Changes in physiology and pathophysiology |
---|---|---|---|---|
Breast | [55] | [59] | Down-regulated | Decreased migration after 5-AZA and TSA treatment [59] |
[57] | ||||
[43] | ||||
[56] | ||||
[59] | ||||
[58] | ||||
Prostate | [62] | Down-regulated | Not described | |
[64] | ||||
[63] | ||||
Bladder | [68] | Down-regulated | Not described | |
Ovarian | [71] | [71] | Down-regulated | Over-expression of CAV1, reduced colony formation and increased apoptosis in ovarian cancer cell line [71] |
Lung | [70] | Down-regulated | Over-expression of CAV1, reduced colony formation in lung cancer cell line [70] | |
Colorectal | [72] | Down-regulated | Not described | |
[73] | ||||
[74] | ||||
Liver | [75] | Down-regulated | Not described | |
[77] |