From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans
Overall | Interaction p for the gene and | |||||
---|---|---|---|---|---|---|
Allele | Phenotype | Effects size (95 % CI) | P | Sex | diabetes | hypertension |
rs60910145 T/G-G/G | Serum creatinine (loge[μmol/l]) | −0.029 (-0.084 to 0.026) | 0.307 | 0.658 | 0.176 | 0.158 |
eGFR (MDRD) [ml/min] | 2.09 (-3.73 to 7.91) | 0.482 | 0.444 | 0.199 | 0.101 | |
eGFR (CKD-EPI) [ml/min] | 3.24 (-1.57 to 8.06) | 0.187 | 0.768 | 0.143 | 0.103 | |
Prevalent CKD (MDRD) | 0.59 (0.18 to 1.89) | 0.350 | 0.677 | 0.081 | 0.410 | |
Prevalent CKD (CKD-EPI) | 0.84 (0.27 to 2.65) | 0.767 | 0.244 | 0.118 | 0.456 | |
Albumin/creatinine ratio (loge[mg/mmol]) | −0.154 (-0.502 to 0.193) | 0.384 | 0.331 | 0.947 | 0.525 | |
Systolic blood pressure (mmHg) | −0.02 (-5.31 to 5.27) | 0.993 | 0.839 | 0.536 | 0.963 | |
rs73885319 A/G-G/G | Serum creatinine (loge[μmol/l]) | −0.026 (-0.080 to 0.028) | 0.341 | 0.612 | 0.260 | 0.273 |
eGFR (MDRD) [ml/min] | 1.75 (-3.93 to 7.44) | 0.546 | 0.402 | 0.283 | 0.181 | |
eGFR (CKD-EPI) [ml/min] | 2.96 (-1.74 to 7.66) | 0.217 | 0.708 | 0.233 | 0.264 | |
Prevalent CKD (MDRD) | 0.56 (0.18 to 1.79) | 0.307 | 0.654 | 0.086 | 0.411 | |
Prevalent CKD (CKD-EPI) | 0.81 (0.26 to 2.54) | 0.720 | 0.233 | 0.123 | 0.455 | |
Albumin/creatinine ratio (loge[mg/mmol]) | −0.096 (-0.436 to 0.245) | 0.583 | 0.240 | 0.883 | 0.411 | |
Systolic blood pressure (mmHg) | −0.020 (-5.18 to 5.14) | 0.994 | 0.834 | 0.585 | 0.837 | |
rs71785313 TTATTA /Del-Del/Del | Serum creatinine (loge[μmol/l]) | 0.020 (-0.024 to 0.064) | 0.382 | 0.549 | 0.801 | 0.891 |
eGFR (MDRD) [ml/min] | −2.35 (-6.99 to 2.30) | 0.323 | 0.479 | 0.865 | 0.893 | |
eGFR (CKD-EPI) [ml/min] | −3.03 (-6.88 to 0.81) | 0.123 | 0.478 | 0.815 | 0.988 | |
Prevalent CKD (MDRD) | 0.91 (0.38 to 2.14) | 0.823 | 0.934 | 0.639 | 0.782 | |
Prevalent CKD (CKD-EPI) | 1.07 (0.43 to 2.66) | 0.890 | 0.971 | 0.487 | 0.622 | |
Albumin/creatinine ratio (loge[mg/mmol]) | 0.050 (-0.214 to 0.314) | 0.710 | 0.587 | 0.854 | 0.889 | |
Systolic blood pressure (mmHg) | 5.60 (1.39 to 9.80) | 0.009 | 0.892 | 0.025 | 0.593 |