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Table 5 Generalized linear and logistic regression models showing the effects of genes on kidney functions and other continuous predictors (dominant model)

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

  

Overall

Interaction p for the gene and

Allele

Phenotype

Effects size (95 % CI)

P

Sex

diabetes

hypertension

rs60910145 T/G-G/G

Serum creatinine (loge[μmol/l])

−0.029 (-0.084 to 0.026)

0.307

0.658

0.176

0.158

 

eGFR (MDRD) [ml/min]

2.09 (-3.73 to 7.91)

0.482

0.444

0.199

0.101

 

eGFR (CKD-EPI) [ml/min]

3.24 (-1.57 to 8.06)

0.187

0.768

0.143

0.103

 

Prevalent CKD (MDRD)

0.59 (0.18 to 1.89)

0.350

0.677

0.081

0.410

 

Prevalent CKD (CKD-EPI)

0.84 (0.27 to 2.65)

0.767

0.244

0.118

0.456

 

Albumin/creatinine ratio (loge[mg/mmol])

−0.154 (-0.502 to 0.193)

0.384

0.331

0.947

0.525

 

Systolic blood pressure (mmHg)

−0.02 (-5.31 to 5.27)

0.993

0.839

0.536

0.963

rs73885319 A/G-G/G

Serum creatinine (loge[μmol/l])

−0.026 (-0.080 to 0.028)

0.341

0.612

0.260

0.273

 

eGFR (MDRD) [ml/min]

1.75 (-3.93 to 7.44)

0.546

0.402

0.283

0.181

 

eGFR (CKD-EPI) [ml/min]

2.96 (-1.74 to 7.66)

0.217

0.708

0.233

0.264

 

Prevalent CKD (MDRD)

0.56 (0.18 to 1.79)

0.307

0.654

0.086

0.411

 

Prevalent CKD (CKD-EPI)

0.81 (0.26 to 2.54)

0.720

0.233

0.123

0.455

 

Albumin/creatinine ratio (loge[mg/mmol])

−0.096 (-0.436 to 0.245)

0.583

0.240

0.883

0.411

 

Systolic blood pressure (mmHg)

−0.020 (-5.18 to 5.14)

0.994

0.834

0.585

0.837

rs71785313 TTATTA /Del-Del/Del

Serum creatinine (loge[μmol/l])

0.020 (-0.024 to 0.064)

0.382

0.549

0.801

0.891

 

eGFR (MDRD) [ml/min]

−2.35 (-6.99 to 2.30)

0.323

0.479

0.865

0.893

 

eGFR (CKD-EPI) [ml/min]

−3.03 (-6.88 to 0.81)

0.123

0.478

0.815

0.988

 

Prevalent CKD (MDRD)

0.91 (0.38 to 2.14)

0.823

0.934

0.639

0.782

 

Prevalent CKD (CKD-EPI)

1.07 (0.43 to 2.66)

0.890

0.971

0.487

0.622

 

Albumin/creatinine ratio (loge[mg/mmol])

0.050 (-0.214 to 0.314)

0.710

0.587

0.854

0.889

 

Systolic blood pressure (mmHg)

5.60 (1.39 to 9.80)

0.009

0.892

0.025

0.593

  1. Models are adjusted for age, sex, diabetes status and hypertension
  2. Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits
  3. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease