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Table 4 Generalized linear and logistic regression models showing the effects of genes on kidney functions and other continuous predictors (recessive model)

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

  

Overall

Allele

Phenotype

Effects size (95 % CI)

P

rs60910145 G/G

Serum creatinine (loge[μmol/l])

0.192 (-0.094 to 0.478)

0.289

 

eGFR (MDRD) [ml/min]

−18.54 (-48.59 to 11.51)

0.227

 

eGFR (CKD-EPI) [ml/min]

−18.90 (-43.76 to 5.96)

0.136

 

Prevalent CKD (MDRD)

23.47 (0.92 to 599.29)

0.074

 

Prevalent CKD (CKD-EPI)

42.72 (1.22 to ∞)

0.047

 

Albumin/creatinine ratio (loge[mg/mmol])

−1.02 (-2.62 to 0.57)

0.210

 

Systolic blood pressure (mmHg)

−0.36 (-27.67 to 26.74)

0.979

rs73885319 G/G

Serum creatinine (loge[μmol/l])

0.191 (-0.094 to 0.478)

0.189

 

eGFR (MDRD) [ml/min]

−18.54 (-48.59 to 11.51)

0.227

 

eGFR (CKD-EPI) [ml/min]

−18.90 (-43.76 to 5.96)

0.136

 

Prevalent CKD (MDRD)

23.47 (0.92 to 599.29)

0.074

 

Prevalent CKD (CKD-EPI)

42.72 (1.22 to ∞)

0.047

 

Albumin/creatinine ratio (loge[mg/mmol])

−1.02 (-2.62 to 0.57)

0.210

 

Systolic blood pressure (mmHg)

−0.36 (-27.67 to 26.94)

0.979

rs71785313 Del/Del

Serum creatinine (loge[μmol/l])

0.038 (-0.144 to 0.219)

0.684

 

eGFR (MDRD) [ml/min]

−7.16 (-26.19 to 11.87)

0.461

 

eGFR (CKD-EPI) [ml/min]

−5.99 (-21.74 to 9.76)

0.456

 

Prevalent CKD (MDRD)

0.0

-

 

Prevalent CKD (CKD-EPI)

0.0

-

 

Albumin/creatinine ratio (loge[mg/mmol])

−0.123 (-1.134 to 0.888)

0.811

 

Systolic blood pressure (mmHg)

−6.27 (-23.55 to 11.02)

0.478

  1. Models are adjusted for age, sex, diabetes status and hypertension
  2. Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits
  3. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease