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Table 4 Size of tests for gene-gene interactions under the various values of M D

From: Jackknife-based gene-gene interaction tests for untyped SNPs

M D of marker G WTT WTT c Truth/ WTT Truth/ WTT c
0.0235 0.008 0.006 0.006 0.006
0.2222 0.016 0.008 0.010 0.009
0.3528 0.011 0.006 0.007 0.005
0.6057 0.011 0.006 0.010 0.008
1 0.007 0.004 0.010 0.008
  1. WTT corresponds to test (5). WTT c corresponds to test (6). Truth/WTT and Truth/ WTT c are test (4) and ICPT on true genotypes, respectively. The values of M D for marker G range from 0.0235 to 1 while the value of M D for marker H is fixed as 0.7615. Number of individuals in cases is 5000. Significance level =0.01. WTT, Wald-type test; WTT c , Wald-type test with constraints