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Table 2 Association between Loci Identified in Populations of European Ancestry and Serum Magnesium in African-American Populations

From: Genetic loci for serum magnesium among African-Americans and gene-environment interaction at MUC1 and TRPM6 in European-Americans: the Atherosclerosis Risk in Communities (ARIC) study

      ARIC study African-American HANDLS study African-American Meta-analysis  
Locus Index SNP in ARIC AA participants Chr Position Coded/Non-coded allele Coded allele freq. Beta SE P-Value Imput. qual. Coded allele freq. Beta P-Value Imput. qual. Beta P-Value P-Value threshold in region
MUC1 rs2974937 1 155168849 C/T 0.32 −0.013 0.002 6.1E-09 0.95 0.35 −0.007 3.5E-02 0.99 −0.012 2.1E-11 8.9E-04
MDS1 rs74516251 3 168830777 A/G 0.11 −0.013 0.003 1.6E-04 0.99 0.11 −0.005 3.3E-01 0.97 −0.011 2.0E-05 4.9E-04
SHROOM3 rs9993810 4 77614640 A/G 0.47 −0.008 0.002 1.8E-04 0.92 0.48 −0.008 3.5E-02 0.93 −0.008 6.1E-06 7.4E-04
TRPM6 rs113607577 9 77455459 G/C 0.90 −0.019 0.004 1.1E-07 0.90 0.89 −0.012 4.7E-02 0.87 −0.017 4.6E-07 1.5E-03
DCDC51 rs7947033 11 30795987 C/T 0.10 −0.011 0.004 5.4E-03 0.74 0.08 −0.001 8.3E-01 0.91 −0.008 1.4E-02 1.0E-03
ATP2B11 rs36089488 12 90118300 T/C 0.95 −0.015 0.005 5.0E-03 0.78 0.94 −0.013 1.0E-01 0.85 −0.015 6.5E-04 9.8E-04
HOXD91 rs6745764 2 176974122 G/A 0.67 −0.008 0.002 9.5E-04 0.82 0.69 −0.005 1.9E-01 0.90 −0.007 3.1E-05 8.5E-04
LUZP2 rs11027876 11 24412973 G/C 0.18 −0.009 0.003 1.3E-03 0.86 0.18 −0.001 8.3E-01 0.89 −0.007 8.1E-03 6.4E-04
PRMT7 rs55857142 16 68236741 T/A 0.07 −0.018 0.004 2.7E-05 0.95 0.07 0.006 3.5E-01 0.97 −0.012 7.1E-04 9.4E-04
  1. Betas are in mmol/L
  2. Abbreviation: freq., frequency; Chr, chromosome; SNP, single nucleotide polymorphism; SE, standard error; imput. qual., imputation quality
  3. Bold indicates significant association in African-American populations based on genome-wide or region-specific p-value threshold and replication in the HANDLS study. The I2, an indicator for heterogeneity between study, was 45 % for the index SNP at MUC1, 0 for SHROOM3, and 8 % for TRPM6