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Table 2 Genome-wide association study results

From: Genome-wide association study of platelet aggregation in African Americans

   

GeneSTAR (AA)

PGAP

GeneSTAR (EA)

SNP_CA

Position

Gene

β(SE)

P-value

MAF

β(SE)

P-value

MAF

β(SE)

P-value

MAF

Epinephrine 2 μM

rs12041331_A

1:155136338

PEAR1

−0.93 (0.13)

2.82 × 10-12

29.2 %

−0.19 (0.05)

4.64 × 10−3

32.8 %

−0.47 (0.18)

4.47 × 10−3

9.1 %

Collagen 2 μg/mL

rs12041331_A

1:155136338

PEAR1

−0.89 (0.13)

2.74 × 10−11

35.8 %

−1.55 (0.59)

9.0 × 10−3

32.1 %

−0.47 (0.18)

0.01

9.1 %

ADP 2 μM

rs12041331_A

1:155136338

PEAR1

−9.2 (1.56)

5.8 × 10−9

35.8 %

−3.65 (2.41)

0.13

33.2 %

−8.52 (1.87)

6.08 × 10−6

9.1 %

rs11924165_T

3:127391893

ALDH1L1-AS2

9.72 (1.68)

1.17 × 10−8

16.9 %

−5.10 (2.86)

0.07

20.0 %

-

-

-*

rs10883735_T

10:104298436

SUFU

−13.9 (2.45)

2.18 × 10−8

5.1 %

1.72 (4.28)

0.69

8.3 %

1.36 (2.45)

0.48

8.1 %

rs11202221_G

10:88592294

BMPR1A

−12.72 (2.30)

4.8 × 10−8

7.3 %

−16.04 (4.06)

7.71 × 10−5

9.1 %

0.60 (1.50)

0.69

20.5 %

ADP 10 μM

rs12041331_A

1:155136338

PEAR1

−5.63 (0.88)

3.2 × 10-10

35.8 %

−3.65 (2.41)

0.13

32.1 %

−2.57 (1.36)

0.06

9.1 %

rs6566765_T

18:69569776

 

4.72 (0.84)

3.59 × 10−8

39.7 %

1.78 (2.49)

0.34

39.3 %

2.01 (0.62)

1.3 × 10−3

35.1 %

rs9889955_G

17:69072972

SDK2

−6.42 (1.15)

4.14 × 10−8

23.5 %

−0.47 (2.71)

0.86

25.9 %

−0.32 (0.74)

0.66

39.3 %†

  1. Abbreviations: SNP single nucleotide polymorphism, CA coded allele, β regression coefficient, SE standard error, GeneSTAR Genetic Study of Atherosclerosis, PGAP Platelet Gene and Physiology, MAF minor allele frequency, ADP adenosine diphosphate, AA African Americans, EA European Americans
  2. Note: In PGAP the epinephrine concentration of 1.5 uM, ADP concentration of 4 uM, and collagen concentration of 2.5 ug/mL were used
  3. * This SNP is monomorphic in population of European descent. Another SNP, rs7611945_A, 231,689 bp upstream of rs11924165 was statistically significant (β(SE) = −4.68 (1.32); p = 4.25 × 10−4; MAF = 20 %) after adjusting for the number of SNPs in between (N = 97) or the number of LD blocks (N = 20)
  4. † Another variant in SDK2 gene, rs11869008_G, located 140,506 bp downstream of rs9889955 was statistically significant (β(SE) = −2.79 (0.84); p = 9.66 × 10−4; MAF = 19.7 %) after adjusting for the number of LD blocks in YRI (N = 25) but not after adjusting for the number of genotyped SNPs (N = 63)
  5. Genome-wide association study results of platelet aggregation in discovery cohort of African Americans and replication cohorts of African Americans and European Americans