From: A colorectal cancer prediction model using traditional and genetic risk scores in Koreans
Colorectal cancer | Colon cancer | Rectal cancer | |||||
---|---|---|---|---|---|---|---|
HR (95% CI) | HR (95% CI)* | HR (95% CI) | HR (95% CI)* | HR (95% CI) | HR (95% CI)* | ||
TRS | Q1 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Q2 | 1.97 (0.95-4.11) | 2.03 (0.98-4.22) | 1.60 (0.52-4.94) | 1.60 (0.52-4.95) | 2.28 (0.87-6.01) | 2.40 (0.91-6.31) | |
Q3 | 2.57 (1.29-5.14) | 2.62 (1.31-5.24) | 2.19 (0.76-6.32) | 2.16 (0.75-6.24) | 2.88 (1.15-7.24) | 3.02 (1.20-7.59) | |
Q4 | 11.29 (6.06-21.1) | 11.54 (6.19-21.5) | 13.33 (5.31-33.5) | 13.27 (5.29-33.3) | 10.16 (4.36-23.7) | 10.59 (4.54-24.7) | |
GRS | Q1 | 1.00 | 1.00 | 1.00 | |||
Q2 | 1.42 (0.77-2.61) | 0.95 (0.47-1.91) | 3.95 (0.93-16.84) | ||||
Q3 | 1.68 (0.92-3.07) | 0.77 (0.37-1.59) | 7.06 (1.70-29.28) | ||||
Q4 | 2.65 (1.43-4.91) | 1.17 (0.55-2.50) | 10.83 (2.58-45.40) | ||||
AUROC | 0.73 (0.69-0.78)† | 0.74 (0.70-0.78) | 0.76 (0.70-0.83)† | 0.75 (0.69-0.81) | 0.71 (0.65-0.77)† | 0.74 (0.68-0.79) | |
NRI | - | 0.17 (-0.05-0.37) | −0.17 (-0.33-0.21) | - | 0.41 (0.10-0.68) | ||
P for NRI | 0.108 | 0.688 | 0.008 |