A colorectal cancer prediction model using traditional and genetic risk scores in Koreans

BMC Genomic Data

Table 2 Hazard ratios for risk factors on risk of CRC: The Korean Cancer Prevention Study-II and the KCPS-II sub-cohort

		KCPS-II cohort (Whole participants)	KCPS-II sub-cohort (Case-cohort design)
Traditional risk factors		HR (95% CI)	HR (95% CI)
Age, year		1.07 (1.06-1.08)	1.08 (1.07-1.10)
Sex (female)		0.65 (0.45-0.92)	0.71 (0.50-1.11)
Log (fasting serum glucose), mg/dL		1.81 (0.99-3.30)	2.16 (0.96-4.83)
Smoking status	Ex-smoker	1.45 (1.03-2.05)	1.74 (1.12-2.72)
	Current smoker	1.28 (0.90-1.83)	1.40 (0.91-2.17)
Exercise (yes)		0.91 (0.70-1.17)	0.68 (0.49-0.94)
Family history of CRC (yes)		2.40 (1.34-4.30)	3.49 (1.70-7.17)
Per 1 SD of TRS increase		1.34 (1.29-1.39)	1.30 (1.24-1.36)

CRC: colorectal cancer, HR: hazard ratios, CI: confidence interval, SD: standard deviation, TRS: traditional risk score,
TRS combined information on above 6 risk factors: age, sex, fasting serum glucose, exercise, and family history of CRC.
KCPS-II: The Korean Cancer Prevention Study-II.

ISSN: 2730-6844