Figure 1
From: The nicotinic acetylcholine receptor alpha 4 subunit contains a functionally relevant SNP Haplotype
Graphical representation of electrophysiological experiments. a) Concentration activation curves for the α4(hap1)β2 and α4(hap2)β2 receptors. To minimize scatter, data were collected from large batches of cells. Data obtained from 70 cells expressing the α4(hap1)β2 are indicated by stars whereas circles correspond to results collected for 65 cells expressing the α4(hap2)β2. Bars indicate the SEM. Continuous curve is the best fit obtained with the sum of two Hill equations for the α4(hap2)β2 and dashed line for the α4(hap1)β2. Representative currents evoked by 100 nM and 30 μM ACh are illustrated in the lower panel. For comparison responses have been normalized to 100% for the largest evoked current. These data illustrate the differential, i.e. inverse, sensitivity at the two concentrations between the two haplotype alleles of the α4β2 receptor.