Figure 1

Heatmap of results for pathway-level methods by the proportion of associated genes within the gene sets. The results are P-values for all pathways using the methods for a complete assessment of performance. Pathways with similar performances will cluster together along the y-axis, as indicated by the dendrogram. Proportion of associated genes (at least one SNP with P < 0.01) is indicated along the x-axis from left (0%) to right (33%). Intensity of color refers to stronger signals (lower P-values), which increases with the proportion of associated genes for most methods.