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Table 2 Association analysis of AKR1B10 variants in the Sorbs population

From: Genetic variants in AKR1B10 associate with human eating behavior

AKR1B10 genotype

 

rs10232478

rs782881

rs1834150

rs3778828

rs4732036

Genotype ( N )

CC (76)

CT (230)

TT (195)

CC (114)

AC (263)

AA (150)

TT (115)

TA (257)

AA (171)

AA (37)

GA (201)

GG (293)

CC (49)

TC (210)

TT (280)

Association analysis with anthropometric traits

BMI (kg/m2)

25.96 ± 3.83

26.42 ± 4.94

25.99 ± 4.09

26.5 ± 4.9

25.9 ± 4.4

26.2 ± 4.1

26.2 ± 4.1

26 ± 4.5

26.1 ± 4.1

26.4 ± 4

25.9 ± 4

26.2 ± 4.7

26.0 ± 4.9

25.9 ± 4.2

26.1 ± 4.4

p-value

n.s.

n.s.

n.s.

n.s.

n.s.

Waist (cm)

87.17 ± 11.70

88.92 ± 13.6

88.91 ± 13.37

87.80 ± 13.1

88.22 ± 12.8

89.18 ± 13.3

87.20 ± 11.8

88.64 ± 13.2

88.76 ± 13.2

87.78 ± 12.6

88.60 ± 12.8

88.20 ± 13.2

88.12 ± 14.9

88.46 ± 12.9

88.33 ± 12.8

p-value

n.s.

"0.001

"0.004

n.s.

n.s.

Hip (cm)

101.6 ± 7.3

103.6 ± 9.2

102.4 ± 7.4

102.61 ± 9.1

106.22 ± 55.8

102.77 ± 7.4

102.37 ± 7.8

106.39 ± 56.4

102.39 ± 7.4

104.14 ± 7.5

102.17 ± 7

105.99 ± 53.0

102.35 ± 9.4

106.67 ± 62.3

102.82 ± 7.9

p-value

n.s.

n.s.

n.s.

n.s.

n.s.

WHR

0.86 ± 0.09

0.86 ± 0.09

0.87 ± 0.1

0.85 ± 0.1

0.85 ± 0.1

0.87 ± 0.1

0.85 ± 0.1

0.86 ± 0.1

0.86 ± 0.1

0.84 ± 0.1

0.86 ± 0.1

0.85 ± 0.1

0.86 ± 0.1

0.86 ± 0.1

0.86 ± 0.1

p-value

n.s.

n.s.

n.s.

n.s.

n.s.

Association analysis with eating behavior factors

Disinhibition

4.95 ± 2.88

4.53 ± 3.16

3.81 ± 2.7

4.9 ± 3.11

4.3 ± 3.02

4.04 ± 2.92

4.93 ± 3.16

4.33 ± 2.95

3.94 ± 2.89

4.65 ± 3.04

4.25 ± 2.99

4.41 ± 3.03

4.29 ± 2.92

4.29 ± 3.12

4.43 ± 2.94

p-value

°0.003

°0.032 "0.037

°0.006 #0.027 "0.022

n.s.

n.s.

Hunger

4.09 ± 2.94

4.04 ± 2.84

3.66 ± 2.66

4.26 ± 2.86

3.83 ± 2.86

3.92 ± 3.10

4.17 ± 2.88

3.85 ± 2.85

3.95 ± 3.04

3.99 ± 3.16

3.99 ± 2.81

3.93 ± 2.98

3.84 ± 2.8

4.07 ± 3.05

3.88 ± 2.86

p-value

n.s.

n.s.

n.s.

n.s.

n.s.

Restraint

8.79 ± 5.32

7.86 ± 4.73

7.62 ± 4.92

8.52 ± 5.13

7.71 ± 4.67

7.65 ± 5.05

8.52 ± 5.09

7.82 ± 4.77

7.6 ± 4.9

7.42 ± 5.03

7.53 ± 4.88

8.31 ± 4.83

7.8 ± 4.37

7.57 ± 4.88

8.24 ± 4.96

p-value

n.s.

n.s.

n.s.

°0.048

n.s.

Association analysis with consumer goods

Smoking

10.04 ± 8.79

10.07 ± 8.13

9.45 ± 8.09

9.91 ± 8.9

10.34 ± 8.18

8.4 ± 7.4

10.6 ± 9.31

9.58 ± 7.95

10.02 ± 8.48

4.67 ± 3.33

10.32 ± 8.98

9.89 ± 8.23

11.94 ± 8.44

9.39 ± 8.35

9.89 ± 8.52

p-value

n.s.

#0.044

n.s.

n.s.

n.s.

Alcohol

2.83 ± 1.2

2.78 ± 1.17

2.82 ± 1.2

2.88 ± 1.18

2.76 ± 1.11

2.79 ± 1.28

2.84 ± 1.23

2.77 ± 1.12

2.79 ± 1.23

2.84 ± 1.30

2.8 ± 1.22

2.77 ± 1.14

2.9 ± 1.19

2.82 ± 1.19

2.75 ± 1.17

p-value

n.s.

n.s.

n.s.

n.s.

n.s.

Coffee

1.79 ± 0.72

1.79 ± 0.76

1.74 ± 0.75

1.81 ± 0.76

1.89 ± 0.82

1.75 ± 0.75

1.81 ± 0.73

1.89 ± 0.82

1.71 ± 0.75

1.62 ± 0.68

1.84 ± 0.82

1.81 ± 0.76

1.71 ± 0.61

1.84 ± 0.79

1.80 ± 0.80

p-value

n.s.

n.s.

#0.043

n.s.

n.s.

  1. Data are presented as mean ± SD. Type 2 diabetics were excluded. P-values were calculated using additive, dominant (mm + mM vs. MM) and recessive (mm vs mM + MM) model of inheritance using linear regression adjusted for age, gender and lnBMI (except for BMI). Analyses for smoking, alcohol and coffee consumption were adjusted for age and gender; ° = additive model of inheritance; # = dominant model of inheritance; “=recessive model of inheritance; n.s. non-significant; significant P-values are highlighted in bold; N = number of individuals; BMI = Body Mass Index; WHR = Waist-Hip-Ratio.