Skip to main content

Table 1 Summary of CNV calls for the Old Order Amish (n = 375) and controls (n = 1897)

From: Copy number variants encompassing Mendelian disease genes in a large multigenerational family segregating bipolar disorder

  Total Deletions Duplications
Amish CNVs Amish Inherited CNVs Controls Amish CNVs Amish inherited CNVs Controls Amish CNVs Amish inherited CNVs Controls
Total Number All Samples 18986 6345 77205 10942 4154 51138 8044 2191 26067
Affected 3844 1380 - 2216 905 - 1628 475 -
Unaffected 12191 3962 - 6922 2581 - 5269 1381 -
Average Size (bp) All Samples 36123 42064 29697 31124 32701 23768 42924 59815 41328
Affected 41123 44572 - 39802 33575 - 42921 65523 -
Unaffected 34363 39932 - 29072 32093 - 41315 54581 -
Burden (per individual) All Samples 50.6 23.2 40.7 29.2 15.2 27.0 21.6 8.2 13.7
Affected 49.9 23.4 - 28.8 15.3 - 21.1 8.1 -
Unaffected 52.1 23.7 - 29.6 15.5 - 22.5 8.3 -
  1. Total number, average size, and burden of CNVs was calculated for all Amish CNVs, inherited Amish CNVs, and control CNVs. CNVs were analyzed together, and as deletion and duplication events separately.