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Table 4 Results of interaction tests between genetic factors and other putative risk factors for DTC

From: Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population

  

rs965513 $ (near FOXE1 )

P-interaction

rs1867277 $ (5′UTR of FOXE1 )

p-interaction

rs71369530 $ (length polymorphism in FOXE1 )

p-interaction

 

G/G

G/A

A/A

 

G/G

G/A

A/A

 

S/S*

L/S*

L/L*

 

Ethnicity

             

African

Cases/controls

25/41

18/28

4/1

 

18/30

23/32

8/12

 

24/37

22/31

3/6

 
 

OR (95% CI)

Ref

1.1 (0.5–2.4)

6.4 (0.7–0.4)

0.3

Ref

1.2 (0.5–2.7)

1.1 (0.4–3.1)

0.4

Ref

1.1 (0.5–2.4)

0.8 (0.2–3.3)

0.09

Other

Cases/controls

56/75

71/49

23/11

 

38/57

81/59

33/20

 

48/73

79/52

27/10

 
 

OR (95% CI)

Ref

2.0 (1.2–3.2)

2.9 (1.3–6.4)

 

Ref

2.0 (1.2–3.5)

2.4 (1.2–4.9)

 

Ref

1.1 (0.5–2.3)

4.0 (1.8–3.2)

 

BMI (kg/m2)

             

≤ Median

Cases/controls

36/63

43/40

10/8

 

25/52

46/48

19/15

 

32/61

45/44

13/9

 
 

OR (95% CI)

Ref

1.9 (1.0–3.4)

2.0 (0.7–5.6)

0.3

Ref

2.0 (1.1–3.7)

1.6 (1.1–6.0)

0.6

Ref

1.9 (1.1–3.5)

2.7 (1.1–6.9)

0.9

> Median

Cases/controls

45/53

46/37

17/4

 

31/35

58/43

22/17

 

40/49

56/39

17/7

 
 

OR (95% CI)

Ref

1.5 (0.8–2.8)

5.7 (1.8–8.6)

 

Ref

1.6 (0.8–3.0)

1.4 (0.6–3.2)

 

Ref

1.8 (1.0–3.2)

2.9 (1.1–7.6)

 

BSA (m2)

             

≤ Median

Cases/controls

37/63

41/44

13/8

 

27/49

49/53

17/16

 

35/62

44/46

15/10

 
 

OR (95% CI)

Ref

1.6 (0.9–2.9)

2.8 (1.1–7.5)

0.8

Ref

1.6 (0.9–3.0)

1.9 (0.8–4.4)

 

Ref

1.7 (0.9–3.0)

2.6 (1.1–6.5)

0.9

> Median

Cases/controls

44/53

48/33

14/4

 

29/38

55/38

24/16

0.9

37/48

57/47

15/6

 
 

OR (95% CI)

Ref

1.8 (1.0–3.4)

4.4 (1.3–14.6)

 

Ref

2.0 (1.0–3.8)

1.9 (0.9–4.3)

 

Ref

2.1 (1.1–3.8)

3.1 (1.1–8.7)

 

Size (m)

             

≤ Median

Cases/controls

42/59

42/41

16/6

 

28/48

58/44

20/16

 

35/55

55/42

16/11

 
 

OR (95% CI)

Ref

1.4 (0.8–2.7)

3.8 (1.4–10.6)

0.7

Ref

2.5 (1.4–4.7)

2.3 (1.0–5.2)

0.3

Ref

2.0 (1.1–3.6)

2.2 (0.9–5.3)

0.5

> Median

Cases/controls

39/57

47/36

11/6

 

30/39

46/57

21/16

 

37/55

46/41

14/5

 
 

OR (95% CI)

Ref

2.0 (1.1–3.6)

2.8 (0.9–8.3)

 

Ref

1.3 (0.7–2.4)

1.7 (0.8_3.8)

 

Ref

1.7 (0.9–3.1)

4.2 (1.4–12.5)

 

Ever smoker

             

No

Cases/controls

57/70

60/46

22/6

 

43/55

71/54

28/16

 

55/68

68/49

21/6

 
 

OR (95% CI)

Ref

1.7 (1.0–2.8)

4.8 (1.8–12.7)

 

Ref

1.7 (1.0–2.9)

2.1 (1.0–4.4)

0.3

Ref

1.7 (1.0–2.8)

4.2 (1.6–11.1)

0.3

Yes

Cases/controls

24/46

29/31

5/6

0.3

13/32

33/37

13/16

 

17/42

33/34

9/10

 
 

OR (95% CI)

Ref

1.8 (0.9–3.7)

1.4 (0.4–5.0)

 

Ref

2.2 (1.0–4.9)

1.9 (0.7–5.1)

 

Ref

2.4 (1.1–5.0)

2.1 (0.7–6.1)

 

Pregnancies

             

<2

Cases/controls

34/68

44/42

10/6

 

23/55

50/48

16/17

 

31/63

46/48

12/8

 
 

OR (95% CI)

Ref

2.0 (1.1–3.7)

3.1 (1.0–9.2)

0.8

Ref

2.5 (1.3–4.6)

2.2 (0.9–5.0)

 

Ref

2.0 (1.1–3.6)

2.9 (1.1–7.9)

 

≥2

Cases/controls

38/30

36/18

12/3

 

25/15

42/30

21/7

0.4

33/27

41/21

16/3

0.7

 

OR (95% CI)

Ref

1.6 (0.8–3.2)

3.1 (0.8–12.1)

 

Ref

0.8 (0.4–1.8)

1.7 (0.6–5.1)

 

Ref

1.6 (0.8–3.3)

4.3 (1.1–16.5)

 
  1. All ORs and tests are stratified on sex and age.
  2. *S for Short alleles (12–14 alanines) and L for Long allele (16–19 alanines).
  3. $Not including missing data.