Table 3 Results of interaction tests between genetic factors and other putative risk factors for DTC

Ethnicity

African

Cases/controls

16/33

21/28

12/12

35/54

14/18

OR (95% CI)

Ref

1.5 (0.7–3.5)

2.3 (0.8–6.3)

Ref

1.2 (0.6–2.7)

Other

Cases/controls

31/37

64/70

58/29

118/108

30/24

OR (95% CI)

Ref

1.1 (0.6–2.0)

2.4 (1.2–4.5)

Ref

1.2 (0.7–2.2)

BMI (kg/m²)

≤ Median

Cases/controls

27/40

33/53

19/22

68/90

21/21

OR (95% CI)

Ref

0.9 (0.4–1.8)

2.1 (1.0–4.4)

Ref

1.3 (0.6–2.4)

> Median

Cases/controls

20/30

52/45

40/19

85/72

23/21

OR (95% CI)

1.7 (0.8–3.4)

3.1 (1.4–6.8)

Ref

1.0 (0.5–1.9)

BSA (m²)

≤ Median

Cases/controls

27/41

32/52

34/24

72/93

20/22

OR (95% CI)

Ref

1.0 (0.5–1.9)

2.2 (1.0–4.4)

Ref

1.2 (0.6–2.4)

> Median

Cases/controls

20/29

53/46

36/17

81/69

24/20

OR (95% CI)

Ref

1.6 (0.6–3.3)

3.1 (1.4–7.0)

Ref

1.0 (0.5–2.0)

Size (m)

≤ Median

Cases/controls

26/39

43/47

36/21

79/84

23/22

OR (95% CI)

Ref

1.3 (0.7–2.6)

2.6 (1.2–5.4)

Ref

1.2 (0.6–2.3)

> Median

Cases/controls

21/31

42/51

34/20

74/78

21/20

OR (95% CI)

Ref

1.3 (0.6–2.5)

2.6 (1.2–57)

Ref

1.0 (0.5–2.1)

Ever smoker

No

Cases/controls

33/46

56/56

54/22

107/98

32/22

OR (95% CI)

Ref

1.2 (0.5–2.7)

1.4 (0.6–3.6)

Ref

1.4 (0.8–2.7)

Yes

Cases/controls

14/24

29/42

16/19

46/64

12/20

OR (95% CI)

Ref

1.4 (0.8–2.5)

3.5 (1.8–7.1)

Ref

0.8 (0.3–0.7)

Pregnancy

<2

Cases/controls

19/39

35/54

35/26

72/91

17/25

OR (95% CI)

Ref

1.3 (0.7–2.6)

2.7 (1.2–5.7)

Ref

0.8 (0.4–1.6)

≥2

Cases/controls

24/21

38/22

27/9

61/46

23/5

OR (95% CI)

Ref

1.5 (0.7–3.4)

2.6 (1.0–6.8)

Ref

3.5 (1.2–9.8)