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Table 2 Association results between the five polymorphisms and the risk of developing DTC

From: Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population

Genotypes

Genotyped participants

Crude OR a (95% CI)

p-value

Adjusted OR b (95% CI)

Adjusted OR per allele (95% CI)

p-value

Cases n (%)

Controls n (%)

rs1801516 (ATM)

n = 197

n = 206

     

G/G

153

162

Ref

 

Ref

  

G/A

44

42

1.2 (0.7–1.9)

0.6

1.2 (0.7–2.0)

1.1 (0.7–1.7)

0.8

A/A

0

2

-

0.9

-

  

rs944289 (near NKX2-1)

n = 202

n = 209

     

C/C

47

70

Ref

 

Ref

  

C/T

85

98

1.3 (0.8–2.0)

0.4

1.2 (0.7–1.9)

1.6 (1.1–2.1)

0.02

T/T

70

41

2.6 (1.5–4.5)

<0.001

2.5 (1.4–4.4)

  

rs965513 (near FOXE1)

n = 203

n = 212

     

G/G

83

118

Ref

 

Ref

  

G/A

91

81

2.0 (1.0–4.1)

0.06

1.7 (1.1–2.6)

1.7 (1.2–2.3)

0.02

A/A

29

13

3.3 (1.16–6.9)

0.001

2.9 (1.3–6.1)

  

rs1867277 (5′UTR of FOXE1)

n = 203

n = 212

     

G/G

56

88

Ref

 

Ref

  

G/A

104

91

1.1 (0.7–1.9)

0.6

1.8 (1.2–2.9)

1.5 (1.1–1.9)

0.01

A/A

43

33

2.1 (1.2–3.8)

<0.01

1.9 (1.1–3.5)

  

rs71369530 (length polymorphism in FOXE1)

n = 203

n = 212

     

S/Sc

72

112

Ref

 

Ref

  

S/Lc

101

84

1.5 (0.8–3.0)

0.2

2.0 (1.3–3.1)

1.8 (1.3–2.5)

0.0003

L/Lc

30

16

2.9 (1.5–5.7)

<0.005

2.9 (1.4–5.9)

  
  1. aStratified by age and sex.
  2. bStratified by age and sex and adjusted on BSA, ethnicity, tobacco, size and for women, number of pregnancies.
  3. cS for alleles with 14 or fewer alanine residues and L for alleles with 16 or more alanine residues.