Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

Table 8 Most significant interactions detected through exhaustive search after main effect SNPs removal

rs number		Chromosome		Position		Marginal effect		p-value ^a	I _OR	R ^2b
rs number		Chromosome		Position		p-value
SNP1	SNP2	SNP1	SNP2	SNP1	SNP2	SNP1	SNP2
rs2254556	rs9267532	6	6	31,374,854	31,672,202	0.008	0.076	1.22E-22	5.23	0.002
rs9267532	rs2523518	6	6	31,672,202	31,373,351	0.076	0.006	3.15E-22	5.15	0.002
rs2596437	rs9267532	6	6	31,371,309	31,672,202	0.006	0.076	7.56E-22	5.1	0.002

^aBold data are genome-wide significant interactions. ^bR² were calculated using controls only.

ISSN: 2730-6844