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Table 7 FORCE Exhaustive search top hits, and PLINK FastEpistasis results in WTCCC psoriasis data

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

SNP pair description   Epistasis search results
First SNP Second SNP FORCE PLINK FastEpistasis
rs number Chromosomal location (position) rs number Chromosomal location (position) u(I OR ) p-value a p-value a
rs4151664 6p21.33 (31,920,873) rs9267532 6p21.33 (31,639,979) 10.588 3.32E-33 4.65E-33
rs4151664 6p21.33 (31,920,873) rs2227956 6p21.33 (31,778,272) 9.662 2.02E-26 7.72E-06
rs3132468 6p21.33 (31,475,486) rs4151664 6p21.33 (31,920,873) 9.571 3.14E-25 1.82E-07
rs9267546 6p21.33 (31,673,436) rs4151664 6p21.33 (31,920,873) 8.340 1.08E-31 2.88E-31
rs4151664 6p21.33 (31,920,873) rs2260000 6p21.33 (31,593,476) 7.749 3.74E-18 1.81E-06
rs2523608 6p21.33 (31,322,559) rs4151664 6p21.33 (31,920,873) 7.695 1.08E-18 4.93E-09
rs4151664 6p21.33 (31,920,873) rs2855807 6p21.33 (31,469,323) 7.444 3.88E-17 3.35E-05
rs2596464 6p21.33 (31,416,156) rs4151664 6p21.33 (31,920,873) 7.379 2.67E-15 5.40E-10
rs3129939 6p21.32 (31,412,961) rs3131296 6p21.32 (32,172,993) 7.376 6.43E-41 4.45E-30
rs2516464 6p21.33 (31,416,156) rs12663103 6p21.32 (32,161,324) 7.229 4.25E-13 3.74E-07
rs6906662 6p21.32 (32,266,506) rs9267649 6p21.33 (31,824,828) 7.187 1.59E-25 2.86E-06
rs12153855 6p21.33 (32,074,804) rs2523608 6p21.33 (31,322,559) 7.181 1.59E-23 6.91E-09
rs4149013 12p12.2 (21,282,410) rs9356206 6q27 (164,818,834) 6.485 9.82E-09 1.11E-05
rs535586 6p21.33 (31,860,337) rs2523589 6p21.33 (31,327,334) 6.299 1.84E-44 5.45E-43
rs2523589 6p21.33 (31,327,334) rs659445 6p21.33 (31,864,304) 6.268 4.08E-45 9.51E-44
rs408359 6p21.32 (32,141,883) rs4151664 6p21.33 (31,920,873) 6.038 4.30E-21 1.64E-21
rs2164182 chr11q21 (95,981,029) rs16864296 1q24.3 (171,236,326) 5.945 8.34E-08 9.86E-06
rs2227956 6p21.32 (31,778,272) rs2523589 6p21.33 (31,327,334) 5.851 1.39E-42 2.91E-42
rs12050395 14q31.3 (86,210,504) rs2301092 5q14.3 (83,363,112) 5.831 1.67E-08 2.33E-06
rs12663103 6p21.32 (32,161,324) rs9267649 6p21.33 (31,824,828) 5.827 4.99E-15 1.21E-02
rs535586 6p21.33 (31,860,337) rs12663103 6p21.32 (32,161,324) 5.810 6.66E-11 2.62E-05
rs9267532 6p21.33 (31,639,979) rs9267487 6p21.33 (31,511,350) 5.806 6.48E-19 3.25E-20
rs9267487 6p21.33 (31,511,350) rs9501587 6p21.33 (31,346,937) 5.804 1.75E-24 1.96E-05
rs12663103 6p21.32 (32,161,324) rs3130637 6p21.33 (31,488,145) 5.800 4.52E-16 2.79E-05
rs2948369 8p22 (12,736,387) rs4077920 8q22.1 (98,893,864) 5.800 6.05E-09 1.90E-07
  1. aBold data are genome-wide significant interactions.