Table 7 FORCE Exhaustive search top hits, and PLINK FastEpistasis results in WTCCC psoriasis data
SNP pair description | Epistasis search results | |||||
|---|---|---|---|---|---|---|
First SNP | Second SNP | FORCE | PLINK FastEpistasis | |||
rs number | Chromosomal location (position) | rs number | Chromosomal location (position) | u(I OR ) | p-value a | p-value a |
rs4151664 | 6p21.33 (31,920,873) | rs9267532 | 6p21.33 (31,639,979) | 10.588 | 3.32E-33 | 4.65E-33 |
rs4151664 | 6p21.33 (31,920,873) | rs2227956 | 6p21.33 (31,778,272) | 9.662 | 2.02E-26 | 7.72E-06 |
rs3132468 | 6p21.33 (31,475,486) | rs4151664 | 6p21.33 (31,920,873) | 9.571 | 3.14E-25 | 1.82E-07 |
rs9267546 | 6p21.33 (31,673,436) | rs4151664 | 6p21.33 (31,920,873) | 8.340 | 1.08E-31 | 2.88E-31 |
rs4151664 | 6p21.33 (31,920,873) | rs2260000 | 6p21.33 (31,593,476) | 7.749 | 3.74E-18 | 1.81E-06 |
rs2523608 | 6p21.33 (31,322,559) | rs4151664 | 6p21.33 (31,920,873) | 7.695 | 1.08E-18 | 4.93E-09 |
rs4151664 | 6p21.33 (31,920,873) | rs2855807 | 6p21.33 (31,469,323) | 7.444 | 3.88E-17 | 3.35E-05 |
rs2596464 | 6p21.33 (31,416,156) | rs4151664 | 6p21.33 (31,920,873) | 7.379 | 2.67E-15 | 5.40E-10 |
rs3129939 | 6p21.32 (31,412,961) | rs3131296 | 6p21.32 (32,172,993) | 7.376 | 6.43E-41 | 4.45E-30 |
rs2516464 | 6p21.33 (31,416,156) | rs12663103 | 6p21.32 (32,161,324) | 7.229 | 4.25E-13 | 3.74E-07 |
rs6906662 | 6p21.32 (32,266,506) | rs9267649 | 6p21.33 (31,824,828) | 7.187 | 1.59E-25 | 2.86E-06 |
rs12153855 | 6p21.33 (32,074,804) | rs2523608 | 6p21.33 (31,322,559) | 7.181 | 1.59E-23 | 6.91E-09 |
rs4149013 | 12p12.2 (21,282,410) | rs9356206 | 6q27 (164,818,834) | 6.485 | 9.82E-09 | 1.11E-05 |
rs535586 | 6p21.33 (31,860,337) | rs2523589 | 6p21.33 (31,327,334) | 6.299 | 1.84E-44 | 5.45E-43 |
rs2523589 | 6p21.33 (31,327,334) | rs659445 | 6p21.33 (31,864,304) | 6.268 | 4.08E-45 | 9.51E-44 |
rs408359 | 6p21.32 (32,141,883) | rs4151664 | 6p21.33 (31,920,873) | 6.038 | 4.30E-21 | 1.64E-21 |
rs2164182 | chr11q21 (95,981,029) | rs16864296 | 1q24.3 (171,236,326) | 5.945 | 8.34E-08 | 9.86E-06 |
rs2227956 | 6p21.32 (31,778,272) | rs2523589 | 6p21.33 (31,327,334) | 5.851 | 1.39E-42 | 2.91E-42 |
rs12050395 | 14q31.3 (86,210,504) | rs2301092 | 5q14.3 (83,363,112) | 5.831 | 1.67E-08 | 2.33E-06 |
rs12663103 | 6p21.32 (32,161,324) | rs9267649 | 6p21.33 (31,824,828) | 5.827 | 4.99E-15 | 1.21E-02 |
rs535586 | 6p21.33 (31,860,337) | rs12663103 | 6p21.32 (32,161,324) | 5.810 | 6.66E-11 | 2.62E-05 |
rs9267532 | 6p21.33 (31,639,979) | rs9267487 | 6p21.33 (31,511,350) | 5.806 | 6.48E-19 | 3.25E-20 |
rs9267487 | 6p21.33 (31,511,350) | rs9501587 | 6p21.33 (31,346,937) | 5.804 | 1.75E-24 | 1.96E-05 |
rs12663103 | 6p21.32 (32,161,324) | rs3130637 | 6p21.33 (31,488,145) | 5.800 | 4.52E-16 | 2.79E-05 |
rs2948369 | 8p22 (12,736,387) | rs4077920 | 8q22.1 (98,893,864) | 5.800 | 6.05E-09 | 1.90E-07 |