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Table 6 Semi-exhaustive search among SNP pairs containing a GWAS-identified SNP

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

GWAS-identified SNP

Highest-scoring interactor with GWAS-identified SNP

FORCE u(I OR )

PLINK FastEpistasis Z-score

rs number

Chromosomal location

Risk allele OR

Single association p-value

rs number

Chromosomal location

u(I OR )

Empirical p-value

Exact p-value a

rs number

Chromosomal location

Exact p-value

rs10484554

6p21.33

4.66

4.0E-214

rs4151664

6p21.33

2.97

<10E-06

7.86E-10

rs28615950

6p21.3

2.12E-14

rs2546890

5q33.3

1.54

1.0E-20

rs7525345

1p31.1

2.53

7.10E-04

2.17E-06

rs4796093

17q12

1.24E-06

rs6701216

1q21

1.45

6.2E-05

rs2156892

22q11.22

2.5

<10E-06

1.30E-13

rs10853580

18q21.1

4.99E-07

rs4112788

1q21.3

1.41

6.5E-09

No pair meeting all inclusion criteria

rs4459983

4q21.1

3.35E-08

rs7993214

13q14.11

1.41

2.0E-06

No pair meeting all inclusion criteria

rs10800559

1q23.3

4.04E-08

rs3213094

5q33.3

1.39

5.0E-11

No pair meeting all inclusion criteria

rs10512686

5p13.1

8.12E-06

rs17716942

2q24

1.29

1.1E-13

rs16928722

10q22.1

2.69

4.10E-06

2.78E-06

rs2553680

8q13.2

5.67E-07

rs20541

5q31.1

1.27

5.0E-15

No pair meeting all inclusion criteria

rs17171818

5q31.2

5.63E-07

rs240993

6q21

1.25

5.3E-20

rs4727157

7q21.12

2.78

<10E-06

1.88E-20

rs2877327

22q12.1

1.26E-07

rs4795067

17q11

1.19

4.0E-11

No pair meeting all inclusion criteria

rs3819847

3q27.3

4.59E-07

rs8016947

14q13

1.19

1.5E-11

No pair meeting all inclusion criteria

rs11071746

15q22.31

1.58E-08

rs610604

6q23

1.19

7.0E-07

rs17585537

3p26.2

2.69

<10E-06

6.47E-19

rs4794888

17q11.1

1.11E-06

rs12580100

12q13.2

1.17

1.0E-06

rs7565742

2q31.2

3.39

<10E-06

6.80E-20

rs2992154

13q21.31

2.07E-06

rs4649203

1p36

1.13

6.8E-08

No pair meeting all inclusion criteria

rs7661684

4q28.1

1.70E-06

rs2201841

1p31.3

1.13

3.0E-08

No pair meeting all inclusion criteria

rs12783252

10q26.11

3.79E-06

rs27524

5q15

1.13

2.6E-11

No pair meeting all inclusion criteria

rs7849719

9q21.31

1.37E-08

rs702873

2p16

1.12

3.6E-09

No pair meeting all inclusion criteria

rs10897897

11q13.4

1.79E-06

rs3134792

6p21.33

NR

1.0E-09

rs1062070

6p21.32

2.88

<10E-06

2.85E-10

rs1062070

6p21.32

5.25E-14

  1. aBold data are genome-wide significant interactions.
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