BMC Genomic Data

Table 3 Penetrances and allele frequencies (p,q) used to simulate the interaction models – from Ritchie [28]

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

Model 1				Model 2				Model 3
	BB	Bb	bb		BB	Bb	bb		BB	Bb	bb
AA	0	0.10	0	AA	0	0	0.10	AA	0.08	0.07	0.05
Aa	0.10	0	0.10	Aa	0	0.05	0	Aa	0.10	0	0.10
aa	0	0.10	0	aa	0.10	0	0	aa	0.03	0.10	0.04
p = 0.5, q = 0.5				p = 0.5, q = 0.5				p = 0.25, q = 0.75
Model 4				Model 5				Model 6
	BB	Bb	bb		BB	Bb	bb		BB	Bb	bb
AA	0	0.01	0.09	AA	0.07	0.05	0.02	AA	0.09	0.001	0.02
Aa	0.04	0.01	0.08	Aa	0.05	0.09	0.01	Aa	0.08	0.07	0.005
aa	0.07	0.09	0.03	aa	0.02	0.01	0.03	aa	0.003	0.007	0.02
p = 0.25, q = 0.75				p = 0.10, q = 0.9				p = 0.10, q = 0.9

Marginal penetrances for each genotype are identical as we simulate pure epistasis effects.

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