Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

Table 12 Family-wise error rate (FWER) of FORCE for the 6 epistatic models and 16 noise conditions tested

Family-wise error rate	Model 1 ^a	Model 2	Model 3	Model 4	Model 5	Model 6
No noise	0.05	0.02	0.02	0.06	0.05	0.04
Genotype errors (GE)	0.03	0.03	0.08	0.03	0.03	0.04
Genetic heterogeneity (GH)	0.02	0.07	0.07	0.04	0.02	0.02
Phenocopy (PC)	0.03	0.05	0.05	0.06	0.04	0.07
Misssing data (MS)	0.07	0.02	0.02	0.03	0.03	0.06
GE + GH	0.05	0.07	0.04	0.03	0.01	0.07
GE + PC	0.05	0.05	0.01	0.02	0.03	0.02
GE + MS	0.02	0.01	0.06	0.04	0.04	0.07
GH + PC	0.05	0.05	0.03	0.02	0.03	0.03
GH + MS	0.04	0.07	0.05	0.03	0.03	0.01
PC + MS	0.03	0.02	0.03	0.06	0.04	0.03
GE + GH + PC	0.07	0.03	0.06	0.03	0.02	0.04
GE + GH + MS	0.07	0.05	0.04	0.01	0.05	0.05
GH + PC + MS	0.04	0.02	0.06	0.02	0.03	0.03
GE + PC + MS	0.05	0.08	0.06	0.06	0.05	0.05
GE + GH + PC + MS	0.02	0.07	0.06	0.04	0.05	0.06

GE: Genotyping errors – GH: Genetic heterogeneity – MS: Missing data – PC: Phenocopy. ^aIn bold, FWER > 0.05.

ISSN: 2730-6844