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Table 10 Power and family-wise error rate (FWER) of FORCE, MBMDR, Plink Epistasis and Plink FastEpistasis on 6 epistasis models without noise or with simulated genetic heterogeneity (GH)

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

    Model 1 Model 2 Model 3 Model 4 Model 5 Model 6
    Both First Either Both First Either Both First Either Both First Either Both First Either Both First Either
FORCE Powera 0.01 0.08 0.14 0.38 0.6 0.82 0.03 0.19 0.34 0.16 0.39 0.62 0.04 0.21 0.38 0.1 0.34 0.57
FWERb 0.02 0.07 0.07 0.04 0.02 0.02
MBMDR Power 0.75 0.86 0.97 0.96 0.98 1 0 0.09 0.17 0.01 0.07 0.13 0 0.07 0.13 0.03 0.16 0.28
FWER 0 0 0 0 0 0
Plink Epistasis Power 0 0 0 0.91 0.96 1 0 0.02 0.03 0.05 0.29 0.52 0 0.13 0.26 0.02 0.25 0.47
FWER 0.01 0.02 0.01 0.05 0 0
FastEpistasis Power 0 0 0 0.96 0.98 1 0 0.02 0.04 0.08 0.31 0.54 0 0.07 0.14 0.02 0.18 0.34
FWER 0.02 0.03 0.01 0.07 0.01 0
  1. aIn bold, power higher than 50%. bIn bold, FWER lower than 5%.