Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population

Chen, Huan; Xu, Junquan; Zhou, Yuxi; Gao, Yong; Wang, Guoqing; Xia, Jiguang; Huen, Michael SY; Siok, Wai Ting; Jiang, Yuyang; Tan, Li Hai; Sun, Yimin

doi:10.1186/s12863-015-0172-5

BMC Genomic Data

Table 1 Association between significant SNP markers and dyslexia using the additive, dominant, genotype, and the recessive models

From: Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population

Gene	SNP	Patient	Control	Crude OR (95%CI)	Unadjusted p-value	Adjusted OR (95%CI)	Adjusted p-value	FDR corrected p-value
GNPTAB	rs17031962
	C Allele	677	678	1.000		1.000
	T Allele	287	340	0.844	0.082	0.748	0.006	0.065
	T Allele	287	340	(0.6977-1.022)	0.082	(0.6079-0.9209)	0.006	0.065
	CC	240	222	1.000		1.000
	CT	197	234	0.779	0.062	0.674	0.007	0.074
	CT	197	234	(0.5986-1.0131)	0.062	(0.5057-0.8977)	0.007	0.074
	TT	45	53	0.785	0.279	0.672	0.093	0.326
	TT	45	53	(0.5072-1.2161)	0.279	(0.4226-1.0687)	0.093	0.326
	Dom			0.780	0.052	0.665	0.003	0.036
	Dom			(0.6074-1.002)	0.052	(0.5056-0.8739)	0.003	0.036
	Rec			0.886	0.571	0.771	0.255	0.596
	Rec			(0.5831-1.346)	0.571	(0.4917-1.207)	0.255	0.596
	rs10778148
	C Allele	854	909	1.000		1.000
	T Allele	110	107	1.090	0.540	1.148	0.368	0.639
	T Allele	110	107	(0.827-1.437)	0.540	(0.8501-1.55)	0.368	0.639
	CC	386	403	1.000		1.000
	CT	82	103	0.831	0.260	0.899	0.547	0.976
	CT	82	103	(0.6024-1.1468)	0.260	(0.6350-1.2722)	0.547	0.976
	TT	14	2	7.308	0.009	7.250	0.014	0.286
	TT	14	2	(1.6501-32.3685)	0.009	(1.5021-34.9920)	0.014	0.286
	Dom			0.955	0.769	1.022	0.897	0.966
	Dom			(0.7001-1.301)	0.769	(0.731-1.43)	0.897	0.966
	Rec			7.568	0.008	7.462	0.012	0.254
	Rec			(1.711-33.48)	0.008	(1.554-35.83)	0.012	0.254
GNPTG	rs2887538
	G Allele	713	709	1.000		1.000
	A Allele	253	309	0.814	0.040	0.850	0.132	0.401
	A Allele	253	309	(0.6689-0.9909)	0.040	(0.6879-1.05)	0.132	0.401
	GG	265	245	1.000		1.000
	AG	183	219	0.773	0.054	0.829	0.195	0.775
	AG	183	219	(0.5944-1.0041)	0.054	(0.6243-1.1006)	0.195	0.775
	AA	35	45	0.719	0.173	0.754	0.275	0.481
	AA	35	45	(0.4473-1.1559)	0.173	(0.4533-1.2525)	0.275	0.481
	Dom			0.763	0.034	0.815	0.138	0.454
	Dom			(0.5947-0.98)	0.034	(0.6225-1.068)	0.138	0.454
	Rec			0.806	0.357	0.816	0.421	0.695
	Rec			(0.5083-1.277)	0.357	(0.4968-1.34)	0.421	0.695
NAGPA	rs882294
	T Allele	785	877	1.000		1.000
	C Allele	179	143	1.404	0.006	1.531	0.002	0.034
	C Allele	179	143	(1.102-1.789)	0.006	(1.176-1.994)	0.002	0.034
	TT	318	377	1.000		1.000
	CT	149	123	1.436	0.012	1.577	0.004	0.074
	CT	149	123	(1.0837-1.9032)	0.012	(1.1609-2.1408)	0.004	0.074
	CC	15	10	1.778	0.166	2.060	0.112	0.337
	CC	15	10	(0.7880-4.0131)	0.166	(0.8443-5.0280)	0.112	0.337
	Dom			1.462	0.006	1.611	0.002	0.036
	Dom			(1.113-1.921)	0.006	(1.197-2.169)	0.002	0.036
	Rec			1.606	0.252	1.793	0.195	0.560
	Rec			(0.7144-3.61)	0.252	(0.742-4.333)	0.195	0.560

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ISSN: 2730-6844

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