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Table 5 The effects of TCA cycle intermediates and their isomers on C. elegans lifespan

From: Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

Treatment Concentration % of untreated mean lifespan p-value # of worms Replicates
succinate 1 mM 111 <0.001 590 4
5 mM 110 <0.001 570 4
10 mM 104 0.098 607 4
citrate1 10 mM 98 0.414 229 2
α-ketoglutarate 0.1 mM 110 <0.001 261 3
1 mM 115 <0.001 345 3
5 mM 111 <0.001 337 3
10 mM 107 0.042 333 3
DL-isocitrate 1 mM 103 0.202 452 4
5 mM 113 <0.001 523 4
10 mM 72 <0.001 217 4
D-malate 1 mM 85 <0.001 106 1
5 mM 76 <0.001 77 1
10 mM 79 <0.001 142 1
  1. 1compared to a medium lacking citrate. All other experiments contain 10 mM citrate as part of the standard culture media.