Skip to main content

Table 3 The effects of amino acids on lifespan in aak-2, sir-2.1 and eat-2 mutant and bec-1 knockdown worms

From: Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

Strain Treatment % of N2 control mean lifespan % of untreated mean lifespan p-value # of worms Replicates
aak-2(gt33) Control 80   <0.001 786 8
5 mM histidine   100 0.877 189 2
5 mM proline   100 0.919 187 2
1 mM alanine   100 0.943 209 2
1 mM tryptophan   102 0.060 220 2
10 mM serine   101 0.137 204 2
5 mM lysine   87 0.373 180 2
5 mM cysteine   85 0.952 140 2
10 mM cysteine   90 0.122 145 2
5 mM tyrosine   80 <0.001 200 2
5 mM glutamine   94 0.436 180 2
10 mM glutamine   103 0.126 200 2
sir-2.1(ok434) Control 86   <0.001 299 4
5 mM histidine   100 <0.830 154 2
5 mM proline   104 0.211 114 2
1 mM alanine   98 0.225 165 2
1 mM tryptophan   102 0.673 121 2
10 mM serine   101 0.482 136 2
10 mM glutamine   110 <0.001 180 2
5 mM cysteine   105 0.244 192 2
10 mM cysteine   110 <0.001 190 2
5 mM tyrosine   93 0.231 131 2
5 mM lysine   107 0.017 146 2
1 mM phenylalanine   105 0.049 155 2
10 mM phenylalanine   101 0.402 176 2
eat-2(ad1116) Control 142   <0.001 135 2
10 mM serine   108 0.078 161 2
1 mM tryptophan   105 0.099 138 2
5 mM glutamine   100 0.841 134 2
5 mM histidine   106 0.091 153 2
5 mM proline   107 0.076 176 2
N2 (bec-1 RNAi) with live bacteria Control 123   <0.001 184 2
1 mM tryptophan   107 <0.001 162 2
10 mM serine   101 0.316 152 2
5 mM histidine   99 0.274 117 2
5 mM proline   98 0.09 102 2