Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

BMC Genomic Data

Table 2 The effects of amino acids on lifespan in daf-16 mutant and skn-1 knockdown C. elegans

Strain	Treatment	% of N2 mean lifespan	% of untreated mean lifespan	p-value	# of worms	Replicates
daf-16(mgDf50)	Control	73		<0.001	608	7
	5 mM histidine		92	<0.001	286	2
	5 mM proline		106	0.0871	133	2
	1 mM alanine		102	0.111	107	2
	1 mM tryptophan		118	0.008	183	2
	10 mM serine		105	0.104	161	2
	10 mM glutamine		95	0.107	125	2
	5 mM cysteine		95	0.107	115	2
	10 mM cysteine		81	<0.001	105	2
	5 mM tyrosine		96	0.578	140	2
	5 mM lysine		99	0.907	130	2
N2 (skn-1 RNAi) with live bacteria	Control	59		<0.001	156	3
	1 mM tryptophan		107	0.042	125	3
	10 mM serine		107	0.01	175	3
	5 mM histidine		103	0.296	139	3
	5 mM proline		105	0.088	111	2
N2 with live bacteria	Control	-			298	5
	1 mM tryptophan		109	<0.001	317	5
	10 mM serine		109	<0.001	375	5
	5 mM histidine		110	<0.001	277	5
	5 mM proline		108	<0.001	268	4

ISSN: 2730-6844