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Table 2 The effects of amino acids on lifespan in daf-16 mutant and skn-1 knockdown C. elegans

From: Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

Strain Treatment % of N2 mean lifespan % of untreated mean lifespan p-value # of worms Replicates
daf-16(mgDf50) Control 73   <0.001 608 7
5 mM histidine   92 <0.001 286 2
5 mM proline   106 0.0871 133 2
1 mM alanine   102 0.111 107 2
1 mM tryptophan   118 0.008 183 2
10 mM serine   105 0.104 161 2
10 mM glutamine   95 0.107 125 2
5 mM cysteine   95 0.107 115 2
10 mM cysteine   81 <0.001 105 2
5 mM tyrosine   96 0.578 140 2
5 mM lysine   99 0.907 130 2
N2 (skn-1 RNAi) with live bacteria Control 59   <0.001 156 3
1 mM tryptophan   107 0.042 125 3
10 mM serine   107 0.01 175 3
5 mM histidine   103 0.296 139 3
5 mM proline   105 0.088 111 2
N2 with live bacteria Control -    298 5
1 mM tryptophan   109 <0.001 317 5
10 mM serine   109 <0.001 375 5
5 mM histidine   110 <0.001 277 5
5 mM proline   108 <0.001 268 4