Figure 3From: Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans Individual supplementation of many TCA cycle metabolites extends mean lifespan in C. elegans . (A) Succinate extends lifespan, (B) citrate does not extend lifespan, (C) alpha-ketoglutarate extends lifespan, and (D) isocitrate extends lifespan at one or more of the concentrations tested. 10Â mM citrate is a standard component of the S-medium. It was removed to determine the effect of citrate on lifespan.Back to article page