Table 2 Meta-analysis of TNF-alpha (−308 G/A) polymorphism and PCOS risk

Overall

7

0.93 (0.77-1.11)^F

0.610

0.61 (0.26-1.41)^F

0.519

0.89 (0.65-1.23)^F

0.725

0.85 (0.63-1.16)^F

0.741

0.66 (0.29-1.49)^F

0.495

HWE in controls/sample size ≤ 200

6

0.82 (0.61-1.10)^F

0.634

0.53 (0.20-1.39)^F

0.397

0.89 (0.63-1.25)^F

0.603

0.84 (0.61-1.17)^F

0.625

0.55 (0.21-1.44)^F

0.389

PCR-RFLP

4

0.91 (0.63-1.32)^F

0.469

0.47 (0.15-1.47)^F

0.236

1.11 (0.72-1.71)^F

0.864

1.00 (0.67-1.52)^F

0.699

0.47 (0.15-1.46)^F

0.245

Ethnicity

Asian

4

0.95 (0.77-1.16)^F

0.523

0.37 (0.10-1.36)^F

0.124

0.96 (0.60-1.52)^F

0.960

0.87 (0.55-1.37)^F

0.893

0.39 (0.04-3.72)^R

0.096

Caucasian

3

0.86 (0.59-1.24)^F

0.354

0.89 (0.29-2.78)^F

0.944

0.84 (0.54-1.30)^F

0.201

0.84 (0.55-1.28)^F

0.234

0.95 (0.31-2.95)^F

0.984

PCOS diagnostic criteria

NIH criteria

2

0.65 (0.44-1.02)^F

0.869

0.31 (0.08-1.19)^F

0.192

0.71 (0.44-1.13)^F

0.345

0.65 (0.41-1.03)^F

0.638

0.35 (0.09-1.30)^F

0.154

Rotterdam criteria

5

1.01 (0.83-1.24)^F

0.955

1.02 (0.33-3.19)^F

0.991

1.08 (0.70-1.66)^F

0.903

1.06 (0.70-1.62)^F

0.930

1.05 (0.36-3.07)^F

0.993