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Table 2 Summary of results for analysis of associations between VDR variants and melanoma risk (total and stratified analysis)

From: Variants Fok1 and Bsm1 on VDR are associated with the melanoma risk: evidence from the published epidemiological studies

Variant Genetic model Total PCC HCC
OR (95% CI) Q/df P a I 2 OR (95% CI) Q/df P a I 2 OR (95% CI) Q/df P a I 2
Bsm1 Bb vs. bb 0.85 (0.76-0.95) 2.46/5 0.782 0% 0.90 (0.78-1.04) 0.44/3 0.933 0% 0.75 (0.60-0.92) NA NA NA
  BB vs. bb 0.83 (0.68-1.00) 6.92/5 0.227 28% 0.81 (0.59-1.13) 6.55/3 0.088 54% 0.78 (0.59-1.04) NA NA NA
  BB + Bb vs. bb 0.85 (0.76-0.94) 3.79/5 0.580 0% 0.89 (0.78-1.02) 1.98/3 0.577 0% 0.75 (0.62-0.92) NA NA NA
Cdx2 GA vs. GG 0.95 (0.81-1.13) 0.49/2 0.784 0% 0.92 (0.76-1.12) 0.03/1 0.867 0% NA NA NA NA
  AA vs.GG 1.00 (0.68-1.46) 1.71/2 0.426 0% 1.10 (0.73-1.67) 0.20/1 0.656 0% NA NA NA NA
  AA + GA vs. GG 0.96 (0.82-1.12) 0.15/2 0.929 0% 0.96 (0.79-1.14) 0.07/1 0.786 0% NA NA NA NA
EcoRV GA vs. AA 1.09 (0.93-1.27) 11. 4/7 0.122 39% 1.12 (0.93-1.36) 9.66/5 0.085 48% 1.00 (0.70-1.41) 1.36/1 0.244 26%
  GG vs. AA 1.09 (0.90-1.33) 10.32/7 0.182 32% 1.00 (0.85-1.18) 4.99/5 0.417 0% 1.63 (0.79-3.36) 2.58/1 0.108 61%
  GA + GG vs. AA 1.09 (0.94-1.26) 10.91/7 0.143 36% 1.09 (0.92-1.29) 8.70/5 0.122 43% 1.15 (0.74-1.78) 2.19/1 0.139 54%
Fok1 Ff vs. FF 1.18 (1.06-1.30) 5.65/8 0.686 0% 1.14 (0.99-1.31) 2.21/4 0.697 0% 1.27 (1.08-1.49) 1.62/2 0.444 0%
  ff vs. FF 1.19 (1.01-1.41) 10.25/8 0.248 22% 1.20 (0.92-1.58) 7.05/4 0.133 43% 1.12 (0.85-1.49) 2.39/2 0.303 16%
  ff + Ff vs. FF 1.18 (1.07-1.29) 7.21/8 0.515 0% 1.15 (1.01-1.31) 3.98/4 0.409 0% 1.24 (1.04-1.49) 2.5/2 0.287 20%
Taq1 Tt vs. TT 1.03 (0.83-1.27) 20.47/6 0.002 71% 1.11 (0.86-1.42) 8.06/3 0.045 63% 0.92 (0.64-1.34) 7.66/2 0.022 74%
  tt vs. TT 0.97 (0.75-1.27) 16.07/6 0.013 63% 1.11 (0.78-1.57) 7.98/3 0.046 62% 0.79 (0.57-1.11) 3.26/2 0.196 39%
  tt + Tt vs. TT 1.03 (0.82-1.28) 24.76/6 < 0.001 76% 1.12 (0.86-1.46) 10.20/3 0.017 71% 0.91 (0.63-1.31) 8.23/2 0.016 76%
Apa1 Aa vs. AA 1.14 (0.94-1.39) 0.46/2 0.795 0% 1.14 (0.94-1.39) 0.46/2 0.795 0% NA NA NA NA
  aa vs. AA 1.07 (0.75-1.54) 3.96/2 0.138 50% 1.07 (0.75-1.54) 3.96/2 0.138 50% NA NA NA NA
  aa + Aa vs. AA 1.12 (0.93-1.34) 1.68/2 0.431 0% 1.12 (0.93-1.34) 1.68/2 0.431 0% NA NA NA NA
  1. aP for heterogeneity test.
  2. Abbreviations: OR odds ratio; 95% CI 95% confidence interval, PCC population-based case–control, HCC hospital-based case–control, NA not applicable.
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