Table 1 Characteristics of studies that have determined associations between common VDR variants and melanoma risk
Study (Ref) | Region | Study type | Participants | SNP site | Genotype in cases | Genotype in controls | Genotyping method | HWE-test |
|---|---|---|---|---|---|---|---|---|
Hutchinson, 2000 [15] | UK | HCC | 316 cases, 108 controls | Fok1 | 105 (FF), 142 (Ff), 45 (ff) | 52 (FF), 44(Ff), 12 (ff) | RFLP | 0.563 |
Taq1 | 94 (TT), 127 (Tt), 40 (tt) | 39 (TT), 41 (Tt), 13 (tt) | RFLP | 0.675 | ||||
Han 2007 [16] | USA | NCC | 219 cases, 873 controls | Fok1 | 77 (FF), 101 (Ff), 37 (ff) | 325 (FF), 418 (Ff), 111 (ff) | Taqman | 0.193 |
Bsm1 | 85 (bb), 94 (Bb), 29 (BB) | 312 (bb), 398 (Bb), 130 (BB) | Taqman | 0.869 | ||||
Cdx2 | 132 (GG), 68 (GA), 5 (AA) | 548 (GG), 269 (GA), 36 (AA) | Taqman | 0.681 | ||||
Santonocito, 2007 [18] | Italy | PCC | 112 cases, 101 controls | Fok1 | 47 (FF), 41 (Ff), 13 (ff) | 41 (FF), 46 (Ff), 14 (ff) | RFLP | 0.849 |
Bsm1 | 37 (bb), 54 (Bb), 10 (BB) | 26 (bb), 51 (Bb), 24 (BB) | RFLP | 0.918 | ||||
EcoRV | 35 (AA), 51 (AG), 15 (GG) | 43 (AA), 45 (AG), 13 GG) | RFLP | 0.819 | ||||
Povey 2007 [17] | UK | PCC | 596 cases, 441 controls | EcoRV | 196 (AA), 297 (AG), 103 (GG) | 130 (AA), 195 (AG), 86 (GG) | RFLP | 0.416 |
Li 2008 [19] | USA | HCC | 805 cases, 841 controls | Taq1 | 330 (TT), 355 (Tt), 120 (tt) | 269 (TT), 422 (Tt), 150 (tt) | RFLP | 0.485 |
Bsm1 | 305 (bb), 366 (Bb), 134 (BB) | 265 (bb), 427 (Bb), 149 (BB) | RFLP | 0.308 | ||||
Fok1 | 287 (FF), 427 (Ff), 91 (ff) | 344 (FF), 396 (Ff), 101 (ff) | RFLP | 0.425 | ||||
Randerson-Moor 2009 (a, [22] ) | UK | PCC | 1028 cases, 402 controls | Cdx2 | 648 (GG), 324 (GA), 56 (AA) | 250 (GG), 134 (GA), 18 (AA) | ASPCR | 0.993 |
EcoRV | 337 (AA), 509 (AG), 182 (GG) | 137 (AA), 188 (AG), 77 (GG) | ASPCR | 0.385 | ||||
Fok1 | 381 (FF), 489 (Ff), 158 (ff) | 161 (FF), 176 (Ff), 65 (ff) | ASPCR | 0.152 | ||||
Bsm1 | 356 (bb), 497 (Bb), 175 (BB) | 134 (bb), 202 (Bb), 66 (BB) | RFLP | 0.488 | ||||
ApaI | 283 (AA), 524 (Aa), 221 (aa) | 120 (AA), 190 (Aa), 92 (aa) | ASPCR | 0.315 | ||||
TaqI | 369 (TT), 484 (Tt), 175 (tt) | 144 (TT), 194 (Tt), 64 (tt) | RFLP | 0.921 | ||||
Randerson-Moor 2009 (b, [22]) | UK | PCC | 299 cases, 560 controls | Cdx2 | 193 (GG), 89 (GA), 17 (AA) | 350 (GG), 179 (GA), 31 (AA) | ASPCR | 0.204 |
EcoRV | 87 (AA), 151 (AG), 61 (GG) | 198 (AA), 261 (AG), 101 (GG) | ASPCR | 0.356 | ||||
Fok1 | 96 (FF), 139 (Ff), 64 (ff) | 225 (FF), 255 (Ff), 80 (ff) | ASPCR | 0.573 | ||||
Bsm1 | 110 (bb), 145 (Bb), 44 (BB) | 134 (bb), 202 (Bb), 66 (BB) | RFLP | 0.488 | ||||
ApaI | 80 (AA), 151 (Aa), 68 (aa) | 175 (AA), 283 (Aa), 102 (aa) | ASPCR | 0.505 | ||||
TaqI | 107 (TT), 150 (Tt), 42 (tt) | 187 (TT), 273 (Tt), 100 (tt) | RFLP | 0.983 | ||||
Gapska 2009 [20] | Poland | PCC | 763 cases, 763 controls | Taq1 | 315 (TT), 351 (Tt), 94 (tt) | 324 (TT), 350 (Tt), 88 (tt) | Taqman | 0.657 |
Bsm1 | 327 (bb), 340 (Bb), 96 (BB) | 308 (bb), 352 (Bb), 98 (bb) | Taqman | 0.869 | ||||
Fok1 | 240 (FF), 377 (Ff), 144 (ff) | 252 (FF), 357 (Ff), 143 (ff) | Taqman | 0.409 | ||||
EcoRV | 237 (AA),370 (AG), 154 (GG) | 216 (AA), 392 (AG), 147 (GG) | Taqman | 0.195 | ||||
Halsall 2009 [21] | USA | HCC | 176 cases, 80 controls | EcoRV | 50 (AA),88 (GA), 38 (GG) | 34 (AA), 46 (GA), 10 (GG) | RFLP | 0.341 |
Pena-Chilet 2013 [23] | Spain | HCC | 530 cases, 314 controls | Taq1 | 186 (TT), 248 (Tt), 64 (tt) | 109 (TT), 141 (Tt), 44 (tt) | Kaspar | 0.884 |
Fok1 | 217 (FF), 225 (Ff), 58 (ff) | 140 (FF) , 130 (Ff) , 39 (ff) | Kaspar | 0.309 | ||||
EcoRV | 183 (AA), 228 (GA), 94 (GG) | 106 (AA), 149 (GA), 45 (GG) | Kaspar | 0.531 | ||||
Zeljic 2014 [24] | Serbia | PCC | 117 cases, 122 controls | EcoRV | 24 (AA), 66 (GA), 27 (GG) | 37 (AA), 51 (GA), 34 (GG) | Taqman | 0.071 |
Fok1 | 40 (FF), 60 (Ff), 17 (ff) | 46 (FF), 62 (Ff), 14 (ff) | Taqman | 0.312 | ||||
Taq1 | 33 (TT), 62 (Tt), 22 (tt) | 59 (TT), 48 (Tt), 15 (tt) | Taqman | 0.192 | ||||
ApaI | 55 (AA), 41 (Aa), 21 (aa) | 52 (AA), 41 (Aa), 29 (aa) | Taqman | 0.001 |