Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population

Table 4 Odds ratios for the SLC6A3 , ANKK1/DRD2 , and CYP2A6 genotypes in current and former smokers

Genotype	Number	OR (95% CI)	P value
SLC6A3 10r/10r	61/16, 57/15	1.362 (0.427–4.344), 1.27 (0.357–4.495)	0.831, 0.975
10r/# or #/#	14/5, 12/4	1.362 (0.427–4.344), 1.27 (0.357–4.495)	0.831, 0.975
ANKK1/DRD2 A2/A2	27/6, 25/6	1.406 (0.488–4.050), 1.231 (0.416–3.642)	0.709, 0.917
A2/A1 or A1/A1	48/15, 44/13	1.406 (0.488–4.050), 1.231 (0.416–3.642)	0.709, 0.917
CYP2A6 1/1	55/18, 49/20	0.458 (0.122–1.725), 0.459 (0.120–1.751)	0.376, 0.387
1/4 or 4/4	20/3, 20/3	0.458 (0.122–1.725), 0.459 (0.120–1.751)	0.376, 0.387

Each analysis was performed for the whole cohort (the left side) and the male subgroup only (the right side). #DAT alleles with less than 10 repeats. Number, current smokers per former smokers; OR, odds ratio; and CI, confidence interval.

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