Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis

Table 2 Characteristics of the four GHRL / GHSR polymorphisms in six studies in breast cancer (BC), colorectal cancer (CRC), esophageal cancer (EC) and Non-Hodgkin’s Lymphoma (NHL)

			Number of
First author (year)	Ethnicity	Cancer type	Cases	Controls	Total	Power (α = 0.05, OR = 1.5)	MAF	HWE
rs696217 Leu72Met GHRL exon 3
Dossus [11]	Europe	Breast	1,324	2,360	3,684	99.9	0.08	0.81
Feigelson [12]	USA	Breast	639	649	1,288	94.8	0.08	0.76
Wagner [14]	Europe	Breast	395	456	851	82.8	0.08	0.84
Campa [23]	Europe	CRC	678	600	1,278	94.6	0.07	0.05
Doecke [10]	Australia	EC	260	1,352	1,612	83.9	0.08	0.05
Skibola [13]	USA	NHL	305	684	989	82.7	0.08	0.59
rs4684677 Gln90Leu GHRL exon 4
Dossus [11]	Europe	Breast	1,311	2,339	3,650	99.9	0.06	0.78
Feigelson [12]	USA	Breast	634	647	1,281	94.7	0.05	0.14
Campa [23]	Europe	CRC	683	600	1,283	94.6	0.07	0.83
Doecke [10]	Australia	EC	260	1,352	1,612	83.9	0.06	0.02
rs2075356 3056 T > C GHRL intron 3/in2c ghrelin 3′UTR
Dossus [11]	Europe	Breast	634	1,734	2,368	99.1	0.09	0.93
Feigelson [12]	USA	Breast	640	652	1,292	94.9	0.10	0.72
Campa [23]	Europe	CRC	667	583	1,250	94.1	0.08	0.05
GHSR rs572169 Gly57Gly GHSR exon 1
Dossus [11]	Europe	Breast	1,327	2,368	3,695	99.9	0.27	0.06
Wagner [14]	Europe	Breast	402	458	860	83.2	0.26	0.004
Campa [23]	Europe	CRC	649	588	1,237	93.9	0.28	0.77

Minor allele frequency (MAF); Hardy-Weinberg Equilibrium (HWE). UTR = untranslated region.

ISSN: 2730-6844