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Table 3 Haplotypic association tests for DN at the 16q22.1-16q22.2 regions a

From: Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population

Haplotypesb

SNPs

H-freq (Cases)

H-freq (Controls)

Crude OR (95% CI)

p-valuec

Adjusted OR (95% CI)

p-valued

Window size of 3-SNP

      

H1 (C-T-G)

rs4985526-rs11647932-rs8062183

0.24

0.14

1.86 (1.72-2.01)

7.36E-05

1.84 (1.70-1.99)

1.10E-04

H2 (T-G-A)

rs11647932-rs8062183-rs2303792

0.24

0.14

1.85 (1.71-2.00)

7.18E-05

1.84 (1.70-1.99)

1.07E-04

H3 (C-C-G)

rs2288491-rs4985534-rs11645214

0.49

0.33

1.92 (1.82-2.02)

5.40E-07

1.93 (1.83-2.03)

6.25E-07

H4 (C-G-G)

rs4985534-rs11645214-rs6499323

0.47

0.33

1.86 (1.76-1.96)

2.08E-06

1.90 (1.80-2.01)

1.48E-06

H5 (G-G-T)

rs11645214-rs6499323-rs7197333

0.47

0.33

1.86 (1.76-1.96)

2.08E-06

1.90 (1.80-2.01)

1.48E-06

H6 (G-T-T)

rs6499323-rs7197333-rs1006985

0.39

0.27

1.73 (1.62-1.84)

4.42E-05

1.85 (1.74-1.97)

8.93E-06

Window size of 4-SNP

      

H7 (T-G-A-G)

rs11647932-rs8062183-rs2303792-rs8052125

0.24

0.14

1.85 (1.71-2.00)

8.22E-05

1.85 (1.71-2.00)

8.04E-05

H8 (G-C-C-G)

rs8052125-rs2288491-rs4985534-rs11645214

0.48

0.33

1.91 (1.81-2.01)

6.99E-07

1.92 (1.82-2.02)

6.56E-07

H9 (C-C-G-G)

rs2288491-rs4985534-rs11645214-rs6499323

0.47

0.33

1.86 (1.76-1.96)

2.08E-06

1.87 (1.77-1.97)

1.76E-06

H10 (C-G-G-T)

rs4985534-rs11645214-rs6499323-rs7197333

0.47

0.33

1.86 (1.76-1.96)

2.08E-06

1.87 (1.77-1.97)

1.76E-06

H11 (G-G-T-T)

rs11645214-rs6499323-rs7197333-rs1006985

0.39

0.27

1.74 (1.63-1.86)

4.63E-05

1.76 (1.65-1.88)

3.16E-05

Window size of 5-SNP

      

H12 (A-G-C-C-G)

rs2303792-rs8052125-rs2288491-rs4985534-rs11645214

0.48

0.33

1.90 (1.80-2.00)

9.62E-07

1.91 (1.81-2.01)

1.15E-06

H13 (G-C-C-G-G)

rs8052125-rs2288491-rs4985534-rs11645214-rs6499323

0.47

0.33

1.86 (1.76-1.96)

2.08E-06

1.90 (1.80-2.01)

1.48E-06

H14 (C-C-G-G-T)

rs2288491-rs4985534-rs11645214-rs6499323-rs7197333

0.47

0.33

1.86 (1.76-1.96)

2.08E-06

1.90 (1.80-2.01)

1.48E-06

H15 (C-G-G-T-T)

rs4985534-rs11645214-rs6499323-rs7197333-rs1006985

0.39

0.27

1.74 (1.63-1.86)

4.72E-05

1.85 (1.74-1.97)

9.85E-06

  1. H-freq: haplotype frequency.
  2. aOnly crude p-value <10-4 was presented.
  3. bA haplotype with a frequency of >0.05 was included in the analysis.
  4. cp-value from logistic regression.
  5. dp-value from logistic regression after adjustment of subject's sex, age, BMI, and durations of diabetes.
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