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Table 1 Demographic and clinical characteristics of study samples

From: Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population

Characteristics

Cases (n = 217)

Controls (n = 357)

p-value

Sociodemographic factors

   

Male

108 (49.8)

170 (47.6)

0.617

Age at enrollment (years)

62.9 × 9.1

62.6 × 9.2

0.673

Diabetes-related variables

   

Age at onset of type 2 diabetes (years)

51.8 × 9.4

52.4 × 9.1

0.463

Durations of diabetes (years)

11.1 × 7.7

10.2 × 7.2

0.154

HbA1c at enrollment (%)

8.2 × 1.7

7.9 × 1.4

0.043

BMI (kg/m2)

26.0 × 3.9

24.7 × 3.5

< 0.001

Lifestyle behaviors

   

Regular exercise

123 (56.7)

260 (72.8)

< 0.001

Smoking status

  

0.926

Ever

33 (15.2)

52 (14.6)

 

Yes

36 (16.6)

56 (15.7)

 

Alcohol drinking

  

0.032

Ever

20 (9.2)

14 (3.9)

 

Yes

34 (15.7)

63 (17.7)

 

Biochemical variables

   

Triglycerides (mg/dL)a

156.8 × 1.8

131.1 × 1.8

< 0.001

Total cholesterol (mg/dL)

192.8 × 53.8

185.9 × 37.2

0.099

HDL-C (mg/dL)

47.0 × 13.9

49.4 × 13.7

0.042

LDL-C (mg/dL)

118.1 × 42.2

117.5 × 33.3

0.856

Creatinine (mg/dL)

1.4 × 1.1

0.7 × 0.2

< 0.001

Uric Acid (mg/dL)

7.4 × 1.9

5.9 × 1.4

< 0.001

BUN (mg/dL)

24.9 × 12.7

15.4 × 4.0

< 0.001

Proteinuria

125 (57.9)

0 (0.0)

< 0.001

eGFR <60 ml/min/1.73 m2

149 (68.7)

0 (0.0)

< 0.001

History of diseases

   

Hypertension

140 (64.5)

156 (43.7)

< 0.001

Heart disease

67 (30.9)

64 (17.9)

< 0.001

Stroke

17 (7.8)

15 (4.2)

0.066

Diabetic retinopathy

41 (18.9)

41 (11.5)

0.014

Diabetic foot

9 (4.2)

5 (1.4)

0.039

  1. Data were presented as mean × SD for continuous variables or n (%) for categorical variables. eGFR: estimated glomerular filtration rate; BUN: blood urea nitrogen.
  2. aGeometric mean was presented.