Figure 1

Comparison of score statistic and threshold with likelihood ratio statistic and permutation threshold. A, compares threshold values (y-axis) across significance levels α (x-axis) with score threshold indicated by the dotted curve and permutation threshold indicated by the solid curve. B, compares the likelihood ratio profile (solid) and score statistic profile (dotted) for one replication; the solid and dotted horizontal lines represent the permutation threshold and score threshold (α = 5%), respectively.