No penalty
|
---|
Haplotype
|
Frequency
|
Realizeda
|
Mean bias
|
Mean SE
|
Coverage
|
P < 0.05b
|
---|
010
|
0.020
|
0.741
|
0.014
|
0.44
|
0.95
|
0.43
|
011
|
0.005
|
0.593
|
-0.663
|
2971.81
|
0.95
|
0.21
|
110
|
0.002
|
0.000
|
-0.971
|
14514.13
|
0.96
|
0.10
|
111
|
0.280
|
0.713
|
0.018
|
0.09
|
0.79
|
1.00
|
001
|
0.050
|
0.012
|
0.050
|
0.28
|
0.91
|
0.09
|
100
|
0.020
|
0.038
|
0.010
|
33.23
|
0.95
|
0.05
|
101
|
0.003
|
0.000
|
-2.212
|
7674.81
|
0.90
|
0.10
|
Ridge penalty
|
Haplotype
|
Frequency
|
Realizeda
|
Mean bias
|
Mean SE
|
Coverage
|
P < 0.05b
|
010
|
0.020
|
0.741
|
-0.135
|
0.73
|
0.85
|
0.18
|
011
|
0.005
|
0.593
|
-0.359
|
1.91
|
0.74
|
0.03
|
110
|
0.002
|
0.000
|
-0.557
|
1.00
|
0.39
|
0.19
|
111
|
0.280
|
0.713
|
-0.010
|
0.11
|
0.83
|
1.00
|
001
|
0.050
|
0.012
|
0.037
|
0.24
|
0.87
|
0.13
|
100
|
0.020
|
0.038
|
0.070
|
1.08
|
1.00
|
0.00
|
101
|
0.003
|
0.000
|
-0.649
|
2.16
|
0.89
|
0.11
|
Difference penalty
|
Haplotype
|
Frequency
|
Realizeda
|
Mean bias
|
Mean SE
|
Coverage
|
P < 0.05b
|
010
|
0.020
|
0.741
|
-0.008
|
0.62
|
0.98
|
0.35
|
011
|
0.005
|
0.593
|
-0.132
|
1.39
|
1.00
|
0.03
|
110
|
0.002
|
0.000
|
-0.272
|
1.00
|
1.00
|
0.15
|
111
|
0.280
|
0.713
|
0.008
|
0.12
|
0.89
|
1.00
|
001
|
0.050
|
0.012
|
0.122
|
0.24
|
0.79
|
0.21
|
100
|
0.020
|
0.038
|
0.131
|
0.88
|
0.93
|
0.07
|
101
|
0.003
|
0.000
|
-0.301
|
1.68
|
0.91
|
0.09
|
- a) "Realized" denotes to the median estimate from the simulated data, where the haplotypes were known, and could be used in the Cox model directly; b) For haplotypes 010, 011, 110 and 111 these percentages reflect power, whereas the percentages for the other three haplotypes reflect type I error probabilities.