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Table 6 MARS results of the analysis of ACTG data with HDL-c levels as trait and SNPs from ApoCIII, ApoE, EL and HL genes and race/ethnicity as predictors

From: Application of two machine learning algorithms to genetic association studies in the presence of covariates

 

Include*

Ignore*

Residualize*

White

(n = 317)

Stratify* Black

(n = 92)

Hispanic

(n = 103)

ApoC-III

      

-482C/T (rs2854117)

4

-

1

1

-

-

-455T/C (rs2854116)

-

3

2

3

-

-

intron 1 (466)G/C (rs2070669)

-

-

-

-

-

-

Gly34Gly C/T (rs4520)

-

-

-

-

-

-

exon 4 SstI 4348(5) C/G (rs5128)

-

-

-

-

-

-

ApoE

      

Arg112Cys T/C (rs429358)

-

-

1

-

-

-

Arg158Cys T/C (rs7412)

3

1

-

2

-

-

EL

      

rs12970066,

5

-

-

4

1

-

Asn396Ser,

4

-

-

1

1

-

rs3829632 (-1309A/G)

-

-

-

-

-

-

HL

      

rs2070895

3

1

-

2

-

-

rs12595191

-

-

-

-

-

-

rs690,

4

2

-

1

-

-

rs6084

2

-

1

-

1

-

Race/ethnicity

1

NA

NA

NA

NA

NA

  1. " * " indicates the approach to handling the race/ethnicity covariate;
  2. "NA" indicates that the predictor was not included in the analysis;
  3. and "-" indicates that the predictor was not selected in the final MARS model.