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Table 4 Summary of results in Table 3

From: Application of two machine learning algorithms to genetic association studies in the presence of covariates

MODEL

Include Z

Residualize by Z

Ignore Z

MODEL 1: ADDITIVE

+/-

+/+

+/+

MODEL 2: ADDITIVE WITH CONFOUNDING

+/-

+/-

- -/-

MODEL 3: ADDITIVE WITH EFFECT MEDIATION

+/-

- -/- -

-/-

MODEL 4: INTERACTION WITH MAIN EFFECT

+/+

+/+

+/+

MODEL 5: INTERACTION WITH NO MAIN EFFECT

+/+

- -/- -

- -/- -

MODEL 6: CONDITIONAL ASSOCIATION

+/+

- -/- -

- -/- -

  1. Results are given in pairs corresponding to RF and MARS, respectively:
  2. "+" denotes reasonable TDR (> 80%) to detect genotype;
  3. "-" denotes lower TDR (50% – 80%) to detect genotype;
  4. and "--" denotes very low TDR (< 50%) to detect genotype.
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BMC Genomic Data

ISSN: 2730-6844

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