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Table 4 Predictions for Genome Wide Associations

From: Linkage disequilibrium compared between five populations of domestic sheep

 

Calculation 1

Calculation 2

Population

T

LD R

P R

mR

M

Total M

WFS

0.2

0.39

0.91

6.08

0.82

4,268

PD

0.2

0.28

0.80

9.20

0.54

6,481

MER

0.2

0.06

0.25

52.4

0.10

35,000

MxB

0.2

0.11

0.45

25.4

0.20

7,000

EMAI

0.2

0.58

0.99

3.42

1.46

2,397

WFS

0.141

0.61

0.99

3

1.58

2,215

PD

0.065

0.78

1.00

2

2.51

1,394

MER

0.151

0.06

0.25

52

0.10

35,000

MxB

0.151

0.28

0.80

9

0.54

6,481

EMAI

0.053

1.00

1.00

na

na

na

  1. In calculation 1, the threshold (T) was set to 0.2 or the empirically derived 5% significance threshold for each population. This allowed the value for LD R to be taken from the dataset and used to calculate P R . The range (R) was set to 0 – 5 cM in each case and mR = 5. In calculation 2, P R was set to 0.95 in each case and the thresholds used were the same as for calculation 1 which resulted in use of the same values for LD R . This allowed the number of markers (mR) for size range (R = 5) to be calculated. mR was converted into the required marker spacing in cM (M) and the total number of markers required for a genome scan (Total M) for each population. The calculation was not applicable (na) where LD was equal to 1.