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Table 2 Allele and genotype frequencies of SNPs in COMT, DRD1, DRD2, DRD3 and DRD4 genes and their association status with diabetic CRI.

From: Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

SNPs

Allele frequency

Genotype frequency

Association

 

DM (n = 225)

CRI (n = 196)

DM (n = 225)

CRI (n = 196)

Allele (df = 1)

Genotype (df = 2)

COMT -287 G>A

G = 0.63

G = 0.65

GG = 0.38

GG = 0.43

χ2 = 0.45;

χ2 = 0.93;

 

A = 0.37

A = 0.35

GA = 0.49

GA = 0.44

P = 0.50

P = 0.63

   

AA = 0.13

AA = 0.13

  

COMT 408 C>G

C = 0.71

C = 0.69

CC = 0.51

CC = 0.47

χ2 = 0.61;

χ2 = 0.98;

 

G = 0.29

G = 0.31

CG = 0.39

CG = 0.44

P = 0.43

P = 0.61

   

GG = 0.10

GG = 0.09

  

COMT 472 G > A (Val158 Met)

G = 0.53

G = 0.59

GG = 0.28

GG = 0.38

χ2 = 2.71;

χ2 = 4.10;

 

A = 0.47

A = 0.41

GA = 0.51

GA = 0.42

P = 0.10

P = 0.13

   

AA = 0.21

AA = 0.20

  

COMT 900 Ins/Del C

Ins = 0.71

Ins = 0.69

Ins/Ins = 0.54

Ins/Ins = 0.46

χ2 = 0.59;

χ2 = 5.83;

 

Del = 0.29

Del = 0.31

Ins/Del = 0.34

Ins/Del = 0.46

P = 0.44

P = 0.054

   

Del/Del = 0.12

Del/Del = 0.08

  

DRD1 -48A>G

A = 0.55

A = 0.82

AA = 0.33

AA = 0.34

χ2 = 0.33;

χ2 = 1.83;

 

G = 0.45

G = 0.18

AG = 0.44

AG = 0.46

P = 0.57

P = 0.401

   

GG = 0.23

GG = 0.20

  

DRD2 -141 ins/del C

Ins = 0.74

Ins = 0.85

Ins/Ins = 0.57

Ins/Ins = 0.74

χ 2 = 12.11;

χ 2 = 11.3;

 

Del = 0.26

Del = 0.15

Ins/Del = 0.35

Ins/Del = 0.23

P < 0.001 a

P = 0.004 a

   

Del/Del = 0.08

Del/Del = 0.03

  

DRD2 G>A

G = 0.77

G = 0.66

GG = 0.61

GG = 0.45

χ 2 = 7.94;

χ 2 = 7.83;

 

A = 0.23

A = 0.34

GA = 0.31

GA = 0.42

P = 0.005

P = 0.02

   

AA = 0.08

AA = 0.13

  

DRD2 T>C

T = 0.74

T = 0.69

TT = 0.55

TT = 0.48

χ2 = 2.30;

χ2 = 2.18;

 

C = 0.26

C = 0.31

TC = 0.37

TC = 0.41

P = 0.13

P = 0.335

   

CC = 0.08

CC = 0.11

  

DRD3 Ser9Gly

C = 0.64

C = 0.59

CC = 0.43

CC = 0.35

χ2 = 2.03;

χ2 = 2.8

 

G = 0.36

G = 0.41

CG = 0.42

CG = 0.48

P = 0.15

P = 0.25

   

GG = 0.15

GG = 0.17

  

DRD4 -120 bp Deletion

Ins = 0.68

Ins = 0.73

Ins/Ins = 0.48

Ins/Ins = 0.53

χ2 = 1.77;

χ2 = 1.72;

 

Del = 0.32

Del = 0.27

Ins/Del = 0.42

Ins/Del = 0.39

P = 0.18

P = 0.42

   

Del/Del = 0.105

Del/Del = 0.08

  

DRD4 -521 C>T

C = 0.40

C = 0.45

CC = 0.18

CC = 0.22

χ2 = 1.25;

χ2 = 1.15;

 

T = 0.60

T = 0.55

CT = 0.44

CT = 0.45

P = 0.26

P = 0.56

   

TT = 0.38

TT = 0.33

  

DRD4 48 bp VNTR

371 = 0.06

371 = 0.08

371/371 = 0.005

371/371 = 0.02

χ2 = 7.25;

χ2 = 10.6;

 

419 = 0.02

419 = 0.02

467/371 = 0.10

467/371 = 0.10

P = 0.30 (df = 6)

P = 0.156 (df = 7)

 

467 = 0.86

467 = 0.80

467/419 = 0.02

467/419 = 0.04

  
 

563 = 0.03

563 = 0.04

467/467 = 0.78

467/467 = 0.68

  
 

611 = 0.01

611 = 0.01

467/563 = 0.02

467/563 = 0.03

  
 

647 = 0.02

647 = 0.04

467/611 = 0.02

467/611 = 0.03

  
   

467/647 = 0.02

467/647 = 0.067

  
   

563/563 = 0.014

419/647 = 0.007

  
  1. aSignificant after Bonferroni's correction α = 0.0042