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Table 1 List of genes included in the study, with sequence screened and SNP frequency

From: Single nucleotide polymorphisms (SNPs) in coding regions of canine dopamine- and serotonin-related genes

Gene

Gene symbol

Gene product category/function*

Bp screened

SNP/bp

Dopamine related genes

Tyrosine hydroxylase

TH

Presynaptic form. of DOPA

1488

1/1488

Dopamine transporter

SLC6A3

Synaptic clearance of Dopamine

1881

1/470

Dopamine receptor D1

DRD1

G protein-coupled receptor

1341

1/335

Dopamine receptor D2

DRD2

G protein-coupled receptor

1332

1/666

Dopamine receptor D3

DRD3

G protein-coupled receptor

1344

1/336

Norepinephrine related gene

Dopamine beta hydroxylase

DBH

Presynaptic form. of norepinephrine

1839

1/306

Serotonin related genes

5-hydroxytryptamine receptor 1A

HTR1A

G protein-coupled receptor

1272

1/1272

5-hydroxytryptamine receptor 1B

HTR1B

G protein-coupled receptor

1170

1/585

5-hydroxytryptamine receptor 1D

HTR1D

G protein-coupled receptor

1134

1/283

5-hydroxytryptamine receptor 1E

HTR1E

G protein-coupled receptor

1098

1/1098

5-hydroxytryptamine receptor 1F

HTR1F

G protein-coupled receptor

1101

1/1101

5-hydroxytryptamine receptor 2A

HTR2A

G protein-coupled receptor

1414

0

5-hydroxytryptamine receptor 2B

HTR2B

G protein-coupled receptor

1305

1/652

5-hydroxytryptamine receptor 2C

HTR2C

G protein-coupled receptor

1377

1/1377

5-hydroxytryptamine receptor 3A

HTR3A

Ligand-gated ion channel

1452

1/1452

5-hydroxytryptamine receptor 4

HTR4

G protein-coupled receptor

1167

0

Serotonin transporter

SLC6A4

Synaptic clearance of Serotonin

1845

0

Tryptophan hydroxylase 1

TPH1

Presynaptic form. of hydroxytryptophan (5HT)

1335

0

Sum of bp screened

  

24895

 

No. of SNPs detected

  

34

 

Frequency of SNPs (snp/bp)

  

1/732

 

   Synonym (n = 23)

  

1/1082

 

   Non-synonym (n = 11)

  

1/2263

 
  1. * As defined at [35]