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Table 3 Simulated genotyping errors and resultant type I error rates.

From: Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites

Error Models §

Mistypes in total genotypes (%)

Misinheritance in mistyped trios (%)

Type I Err. (p ≤ 0.05) Rate (95% C.I.)

A

0.50

27

.0504 (.0499–.0508)

B

0.90

59

.0502 (.0498–.0506)

C

2.70

59

.0502 (.0497–.0506)

D

0.90

59

.0500 (.0496–.0505)

E

0.15

41

.0499 (.0495–.0503)

F

0.17

88

.0502 (.0498–.0507)

ALL

5.23

57

.0506 (.0502–.0511)

  1. § A: mis-scoring genotype (x,x) as (x,x+2); B: mis-scoring genotype (x,x+2) as (x,x); C: short allele dominance; D: binning error; E: priming site mutation (Null allele); F: microsatellite mutation; ALL: all of above.