Figure 4

Power of the TDT tests under different marker-disease association models. RR(lin) designates the linear model, and RR(thr#) the threshold model, where # denotes the first allele with higher risk (Table 2). Number of alleles is set to 6, with equal allele frequencies, i.e. F6.eq in Table 2. "TDT_L/S" is the TDT_L/S method using medium allele length as threshold, "TDT_L/S_kn" is the TDT_L/S method when the threshold is known and is used in the test. Power is calculated from 10,000 simulations on 150 trios, using significant criteria 0.001.