A multi-marker test based on family data in genome-wide association study

BMC Genomic Data

Table 1 Type I error rates of the MPDT and TDT

M	M₁	With LD between markers		Without LD between markers
		TDT	MPDT	TDT	MPDT
100	1	0.051	0.040	0.052	0.049
	5	0.053	0.046	0.057	0.061
	10	0.052	0.051	0.045	0.049
	50	0.044	0.053	0.039	0.039
	100	0.046	0.061	0.039	0.051
1,000	5	0.055	0.061	0.048	0.042
	10	0.052	0.037	0.040	0.061
	50	0.048	0.061	0.044	0.041
	100	0.049	0.042	0.048	0.044
	1,000	0.045	0.059	0.059	0.042
100,000	1,000	0.053	0.040	0.045	0.057
	10,000	0.053	0.050	0.042	0.053
	30,000	0.039	0.045	0.047	0.050
	50,000	0.039	0.049	0.042	0.056
	100,000	0.053	0.060	0.049	0.052

M is the total number of markers and M₁ is the number of markers retained in the first stage.

ISSN: 2730-6844